Evidence map›Paper›PMID 27240827›Full record

ReviewStem cell reviews and reports2016

Multipotent Differentiation of Human Dental Pulp Stem Cells: a Literature Review.

N Nuti, C Corallo, B M F Chan, M Ferrari, B Gerami-Naini

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 3 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 3 syntheses or guidelines pooled it, 308 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Isolation methods of exosomes derived from dental stem cells.International journal of oral science · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Frontiers in cell and developmental biology · 2025
    Article
  18. Chios gum mastic enhance the proliferation and odontogenic differentiation of human dental pulp stem cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
  19. Article
  20. Article

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

N NutiDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
C CoralloDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy. corallo.claudio@gmail.com.
B M F ChanDepartment of Orthodontics, School of Dental Medicine, Tufts University, Medford, MA, USA.
M FerrariDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
B Gerami-NainiDepartment of Diagnostic Science, School of Dental Medicine, Tufts University, Medford, MA, USA.
University of Siena · ITTufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of regenerative medicine has brought us the opportunity to regenerate, modify and restore human organs function. Stem cells, a key resource in regenerative medicine, are defined as clonogenic, self-renewing, progenitor cells that can generate into one or more specialized cell types. Stem cells have been classified into three main groups: embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult/postnatal stem cells (ASCs). The present review focused the attention on ASCs, which have been identified in many perioral tissues such as dental pulp, periodontal ligament, follicle, gingival, alveolar bone and papilla. Human dental pulp stem cells (hDPSCs) are ectodermal-derived stem cells, originating from migrating neural crest cells and possess mesenchymal stem cell properties. During last decade, hDPSCs have received extensive attention in the field of tissue engineering and regenerative medicine due to their accessibility and ability to differentiate in several cell phenotypes. In this review, we have carefully described the potential of hDPSCs to differentiate into odontoblasts, osteocytes/osteoblasts, adipocytes, chondrocytes and neural cells.

Indexed as

AnimalsCell DifferentiationDental PulpHumansRegenerative MedicineStem CellsTissue EngineeringDental pulpDPSCsRegenerative medicineStem cellsTissue engineering

Identifiers

PMID27240827
OpenAlexW2419224960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.