ArticleeLife2016
Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration.Cell reports · 2026Article
- Allometry of cell types in planarians by single-cell transcriptomics.Science advances · 2025Article
- Ets-1 transcription factor regulates glial cell regeneration and function in planarians.Development (Cambridge, England) · 2023Article
- Quantitative Analysis of Planarian Pigmentation.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Single-cell transcriptomics in planaria: new tools allow new insights into cellular and evolutionary features.Biochemical Society transactions · 2022Review
- Defined diets for freshwater planarians.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye-brain-independent movement and arousal.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reactive oxygen species rescue regeneration after silencing the MAPK-ERK signaling pathway in Schmidtea mediterranea.Scientific reports · 2021Article
- Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment.PLoS genetics · 2020Article
- CaCold Spring Harbor perspectives in biology · 2019Review
- A modular laboratory course using planarians to study genes involved in tissue regeneration.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2019Article
- Article
- Cell type transcriptome atlas for the planarianScience (New York, N.Y.) · 2018Article
- Article
- FOX and ETS family transcription factors regulate the pigment cell lineage in planarians.Development (Cambridge, England) · 2017Article
- Planarian finds time(less) to fight infection.Virulence · 2017Article
- The planarianThe Journal of experimental biology · 2017Article
- Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian.Cell discovery · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Porphyrias are disorders of heme metabolism frequently characterized by extreme photosensitivity. This symptom results from accumulation of porphyrins, tetrapyrrole intermediates in heme biosynthesis that generate reactive oxygen species when exposed to light, in the skin of affected individuals. Here we report that in addition to producing an ommochrome body pigment, the planarian flatworm Schmidtea mediterranea generates porphyrins in its subepithelial pigment cells under physiological conditions, and that this leads to pigment cell loss when animals are exposed to intense visible light. Remarkably, porphyrin biosynthesis and light-induced depigmentation are enhanced by starvation, recapitulating a common feature of some porphyrias - decreased nutrient intake precipitates an acute manifestation of the disease. Our results establish planarians as an experimentally tractable animal model for research into the pathophysiology of acute porphyrias, and potentially for the identification of novel pharmacological interventions capable of alleviating porphyrin-mediated photosensitivity or decoupling dieting and fasting from disease pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.