Evidence map›Paper›PMID 27240657›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016

Brain Stimulation in Addiction.

Michael C Salling, Diana Martinez

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05350033 (Transcranial Direct Current Stimulation on Inhibitory Control in Addictions), which is not on this map. Cited by 67 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 7 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05350033 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Transcranial Direct Current Stimulation on Inhibitory Control in Addictions: a Triple-blinded, Sham-controlled Clinical Trial.

TypeinterventionalSponsorUniversidad de AlmeriaRan2021 to 2022Enrolled200ConditionsSubstance-Related DisordersArmstDCS - tDCS, tDCS - Sham, Sham - tDCS, Sham - Sham
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 7 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Article
  13. Article
  14. Article
  15. Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael C SallingDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Diana MartinezDepartment of Psychiatry, Columbia University, New York, NY, USA.
Columbia University · USNew York Psychoanalytic Society and Institute · US

Funding

Prefrontal cortex and adolescent binge drinking: Role of HCN channelsR01AA023531 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HARRISON, NEIL L., SIEGELBAUM, STEVEN A · 2015 to 2019
$1.9M
Using PET to Image the Neurochemistry of AddictionK02DA026525 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARTINEZ, DIANA M · 2009 to 2018
$1.3M
Imaging the Effect of rTMS on Brain Activity in Cocaine AbusersR21DA034433 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MARTINEZ, DIANA M · 2012 to 2013
$407k
NIAAA NIH HHS R01 AA023531NIDA NIH HHS K02 DA026525NIDA NIH HHS R21 DA034433
6 · The paper itself

Abstract

Localized stimulation of the human brain to treat neuropsychiatric disorders has been in place for over 20 years. Although these methods have been used to a greater extent for mood and movement disorders, recent work has explored brain stimulation methods as potential treatments for addiction. The rationale behind stimulation therapy in addiction involves reestablishing normal brain function in target regions in an effort to dampen addictive behaviors. In this review, we present the rationale and studies investigating brain stimulation in addiction, including transcranial magnetic stimulation, transcranial direct current stimulation, and deep brain stimulation. Overall, these studies indicate that brain stimulation has an acute effect on craving for drugs and alcohol, but few studies have investigated the effect of brain stimulation on actual drug and alcohol use or relapse. Stimulation therapies may achieve their effect through direct or indirect modulation of brain regions involved in addiction, either acutely or through plastic changes in neuronal transmission. Although these mechanisms are not well understood, further identification of the underlying neurobiology of addiction and rigorous evaluation of brain stimulation methods has the potential for unlocking an effective, long-term treatment of addiction.

Indexed as

AnimalsBehavior, AddictiveBrainDeep Brain StimulationHumansTranscranial Direct Current StimulationTranscranial Magnetic Stimulation

Identifiers

PMID27240657
PMCPMC5061891
OpenAlexW2409572319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.