Evidence map›Paper›PMID 27240645›Full record

ReviewLeukemia & lymphoma2016

Contemporary insights into the pathogenesis and treatment of chronic myeloproliferative neoplasms.

Tariq I Mughal, Omar Abdel-Wahab, Raajit Rampal, Ruben Mesa, Steffen Koschmieder, Ross Levine, Rüdiger Hehlmann, Giuseppe Saglio, Tiziano Barbui, Richard A Van Etten

Abstract readReview
In one paragraph

Review in Leukemia & lymphoma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tariq I Mughala Tufts University Medical Center , Boston , MA , USA ;
Omar Abdel-Wahabb Memorial Sloan Kettering Cancer Center , New York , NY , USA ;
Raajit Rampalb Memorial Sloan Kettering Cancer Center , New York , NY , USA ;
Ruben Mesac Mayo Clinic Cancer Center , Scottsdale , AZ , USA ;
Steffen Koschmiederd Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine , RWTH Aachen University , Aachen , Germany ;
Ross Levineb Memorial Sloan Kettering Cancer Center , New York , NY , USA ;
Rüdiger Hehlmanne Hematology, Universität Heidelberg , Mannheim , Germany ;
Giuseppe Sagliof Orbassano University Hospital , Turin , Italy ;
Tiziano Barbuig Papa Giovani XXIII Hospital and Research Center , Bergamo , Italy ;
Richard A Van Ettenh Chao Family Comprehensive Cancer Center, University of California Irvine , Irvine , CA , USA.

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
Genomic profiling and development of murine models of transformation of MPNsK08CA188529 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI RAMPAL, RAAJIT · 2014 to 2018
$891k
Role of ASXL1 mutations in myeloid malignanciesK08CA160647 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ABDEL-WAHAB, OMAR · 2011 to 2015
$849k
NCI NIH HHS K08 CA160647NCI NIH HHS K08 CA188529NCI NIH HHS L30 CA153312
6 · The paper itself

Abstract

This review is based on the deliberations at the 5th John Goldman Colloquium held in Estoril on 2nd October 2015 and the 9th post-ASH International Workshop on chronic myeloid leukemia (CML) and BCR-ABL1-negative myeloproliferative neoplasms (MPN) which took place on the 10th-11th December 2014, immediately following the 56th American Society of Hematology Annual Meeting. It has been updated since and summarizes the most recent advances in the biology and therapy of these diseases, in particular updates of genetics of MPN, novel insights from mouse MPN models, targeting CML stem cells and its niche; clinical advances include updates on JAK2 inhibitors and other therapeutic approaches to BCR-ABL1-negative MPNs, the use of alpha interferons, updates on tyrosine kinase inhibitors (TKI) randomized trials in CML, TKI cessation studies, and optimal monitoring strategies.

Indexed as

AnimalsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsDisease Models, AnimalGenetic Predisposition to DiseaseHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiceMolecular Targeted TherapyMutationMyeloproliferative DisordersProtein Kinase InhibitorsRisk AssessmentTreatment OutcomeAntineoplastic AgentsProtein Kinase InhibitorsMolecular geneticsmyeloid leukemias and dysplasiasstem and primitive progenitor cells

Identifiers

PMID27240645
PMCPMC6077976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.