Evidence map›Paper›PMID 27240594›Full record

ArticleBrain structure & function2017

Human ROBO1 regulates white matter structure in corpus callosum.

Fahimeh Darki, Satu Massinen, Elina Salmela, Hans Matsson, Myriam Peyrard-Janvid, Torkel Klingberg, Juha Kere

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Fahimeh DarkiDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Satu MassinenResearch Programs Unit, Haartman Institute, University of Helsinki, Helsinki, Finland.
Elina SalmelaResearch Programs Unit, Haartman Institute, University of Helsinki, Helsinki, Finland.
Hans MatssonDepartment of Biosciences and Nutrition, Karolinska Institutet, Hälsovägen 7, 14183, Huddinge, Sweden.
Myriam Peyrard-JanvidDepartment of Biosciences and Nutrition, Karolinska Institutet, Hälsovägen 7, 14183, Huddinge, Sweden.
Torkel KlingbergDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Juha KereResearch Programs Unit, Haartman Institute, University of Helsinki, Helsinki, Finland. juha.kere@ki.se.
Karolinska Institutet · SEUniversity of Helsinki · FIFolkhälsans Forskningscentrum · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter density in the posterior part of the corpus callosum pathways. One of the polymorphisms, rs7631357, was also significantly associated with the probability of connections to the parietal cortical regions. Our results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.

Indexed as

AdolescentAdultChildCorpus CallosumDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingGenotypeHumansNerve Tissue ProteinsNeural PathwaysParietal LobePolymorphism, Single NucleotideReceptors, ImmunologicRoundabout ProteinsWhite MatterYoung AdultNerve Tissue ProteinsReceptors, ImmunologicRoundabout ProteinsAxonal pathfindingAxon guidance receptor homolog 1DTIRoundaboutSingle nucleotide polymorphismStructural MRI

Identifiers

PMID27240594
PMCPMC5334444
OpenAlexW2409472024

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.