ArticleInhalation toxicology2016
Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice.
Article in Inhalation toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Differential gene expression in nasal airway epithelium from overweight or obese youth with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Pooled it
- Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings.Journal of environmental health science & engineering · 2026Review
- Associations between multiple air pollutants and insulin resistance in Chinese adults: the moderating role of physical activity.BMC public health · 2026Article
- The Impact of the First Trimester and Second Trimester Temperature, Air Pollutants, and Seasonal Variations on the Risk of Gestational Diabetes Mellitus in Twin Pregnancies.Journal of diabetes research · 2025Article
- Article
- Prenatal ozone exposure is associated with children overweight and obesity: Evidence from the Shanghai Maternal-Child Pairs Cohort.Eco-Environment & Health · 2024Article
- Association of Gaseous Ambient Air Pollution and Dementia-Related Neuroimaging Markers in the ARIC Cohort, Comparing Exposure Estimation Methods and Confounding by Study Site.Environmental health perspectives · 2024Article
- Article
- The association between outdoor air pollution and body mass index, central obesity, and visceral adiposity index among middle-aged and elderly adults: a nationwide study in China.Frontiers in endocrinology · 2023Article
- Physical Activity in Polluted Air-Net Benefit or Harm to Cardiovascular Health? A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2021Review
- Review
- Transcriptomics Underlying Pulmonary Ozone Pathogenesis Regulated by Inflammatory Mediators in Mice.Antioxidants (Basel, Switzerland) · 2021Article
- Pulmonary and vascular effects of acute ozone exposure in diabetic rats fed an atherogenic diet.Toxicology and applied pharmacology · 2021Article
- Peripheral metabolic effects of ozone exposure in healthy and diabetic rats on normal or high-cholesterol diet.Toxicology and applied pharmacology · 2021Article
- Diets enriched with coconut, fish, or olive oil modify peripheral metabolic effects of ozone in rats.Toxicology and applied pharmacology · 2021Article
- Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains.Environmental health perspectives · 2020Article
- Ozone Activates the Nrf2 Pathway and Improves Preservation of Explanted Adipose Tissue In Vitro.Antioxidants (Basel, Switzerland) · 2020Article
- Oxidative stress pathways of air pollution mediated toxicity: Recent insights.Redox biology · 2020Review
- TmRelish is required for regulating the antimicrobial responses to Escherichia coli and Staphylococcus aureus in Tenebrio molitor.Scientific reports · 2020Article
- The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundInhaled ozone (O3) has been demonstrated as a harmful pollutant and associated with chronic inflammatory diseases such as diabetes and vascular disorders. However, the underlying mechanisms by which O3 mediates harmful effects are poorly understood.
objectivesTo investigate the effect of O3 exposure on glucose intolerance, immune activation and underlying mechanisms in a genetically susceptible mouse model.
methodsDiabetes-prone KK mice were exposed to filtered air (FA), or O3 (0.5 ppm) for 13 consecutive weekdays (4 h/day). Insulin tolerance test (ITT) was performed following the last exposure. Plasma insulin, adiponectin, and leptin were measured by ELISA. Pathologic changes were examined by H&E and Oil-Red-O staining. Inflammatory responses were detected using flow cytometry and real-time PCR.
resultsKK mice exposed to O3 displayed an impaired insulin response. Plasma insulin and leptin levels were reduced in O3-exposed mice. Three-week exposure to O3 induced lung inflammation and increased monocytes/macrophages in both blood and visceral adipose tissue. Inflammatory monocytes/macrophages increased both systemically and locally. CD4 + T cell activation was also enhanced by the exposure of O3 although the relative percentage of CD4 + T cell decreased in blood and adipose tissue. Multiple inflammatory genes including CXCL-11, IFN-γ, TNFα, IL-12, and iNOS were up-regulated in visceral adipose tissue. Furthermore, the expression of oxidative stress-related genes such as Cox4, Cox5a, Scd1, Nrf1, and Nrf2, increased in visceral adipose tissue of O3-exposed mice.
conclusionsRepeated O3 inhalation induces oxidative stress, adipose inflammation and insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.