ReviewInternational journal of environmental research and public health2016
BMI and BMD: The Potential Interplay between Obesity and Bone Fragility.
Review in International journal of environmental research and public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05163743 (COVID-19 Vaccination in Subjects With Obesity), which is not on this map. Cited by 115 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
COVID-19 Vaccination in Subjects With Obesity: Impact of Metabolic Health and the Role of a Ketogenic Diet
Who cites it
115 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fracture risk following bariatric surgery: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Trial
- Effect of Weight Change Following Intentional Weight Loss on Bone Health in Older Adults with Obesity.Obesity (Silver Spring, Md.) · 2019Trial
- Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women.Hormone research in paediatrics · 2019Trial
- Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways.Archives of toxicology · 2026Article
- Prevalence and Associated Risk Factors of Osteoporosis in Community-Dwelling Older Adults in China: A Cross-Sectional Study of 2533 Participants.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- The Obesity-Bone Paradox in Postmenopausal Women: Divergent Associations of BMI with Bone Mineral Density and Trabecular Bone Score in a Real-World DXA Cohort.Medicina (Kaunas, Lithuania) · 2026Observational
- Defined Microbiota Modulates Host Metabolome and Skeletal Adaptation to Diet-Induced Obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Risk Factors for Osteoporotic Vertebral Fractures in Postmenopausal Women: A Cross-Sectional Study.Journal of orthopaedic case reports · 2026Article
- Combined metabolic stress and nitric oxide synthase inhibition induces tissue-specific remodeling across cardiovascular and hematopoietic compartments during obesity.Frontiers in cardiovascular medicine · 2026Article
- Impact of metabolic score for visceral fat on bone health in adolescent population: a cross-sectional study perspective.Frontiers in nutrition · 2026Article
- Development and validation of a robust logistic regression model for predicting osteoporosis in older people.Frontiers in medicine · 2026Article
- The association between dietary acid load and Kidney/Liver function in morbidly obese bariatric candidates.BMC nutrition · 2025Article
- Integrating Radiology and Metabolic Risk: DEXA-Based Characterization of Bone Health in Type 2 Diabetes.Metabolites · 2025Article
- Article
- Prevalence and Determinants of Impaired Bone Mineral Density and Fractures in the First National Dutch Wilms Tumor Survivor Cohort, a National DCCSS-LATER Study.Cancer medicine · 2025Article
- Bone Health in Metabolic Syndrome-Is It a Neglected Aspect of Dysmetabolic-Related Diseases?Journal of clinical medicine · 2025Review
- Association of CVAI with BMD, FRAX scores, and osteoporosis risk in Chinese elderly patients with hypertension.Scientific reports · 2025Article
- Clinical Validation of Commercial AI Software for the Detection of Incidental Vertebral Compression Fractures in CT Scans of the Chest and Abdomen.Diagnostics (Basel, Switzerland) · 2025Article
- Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence demonstrating an increased fracture risk among obese individuals suggests that adipose tissue may negatively impact bone health, challenging the traditional paradigm of fat mass playing a protective role towards bone health. White adipose tissue, far from being a mere energy depot, is a dynamic tissue actively implicated in metabolic reactions, and in fact secretes several hormones called adipokines and inflammatory factors that may in turn promote bone resorption. More specifically, Visceral Adipose Tissue (VAT) may potentially prove detrimental. It is widely acknowledged that obesity is positively associated to many chronic disorders such as metabolic syndrome, dyslipidemia and type 2 diabetes, conditions that could themselves affect bone health. Although aging is largely known to decrease bone strength, little is yet known on the mechanisms via which obesity and its comorbidities may contribute to such damage. Given the exponentially growing obesity rate in recent years and the increased life expectancy of western countries it appears of utmost importance to timely focus on this topic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.