ArticleMolecules (Basel, Switzerland)2016
Phenolic Profile and Antioxidant Potential of Leaves from Selected Cotoneaster Medik. Species.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 32 citations in OpenAlex.
- Integrated analysis of nutritional composition, phytochemical, and antioxidant activity in Cotoneaster microphyllus (Wall. ex Lindl.).Scientific reports · 2026Article
- Green Synthesised Silver Nanoparticle From Cotoneaster horizontalis, In Vitro and In Silico Antibacterial Properties.Chemistry & biodiversity · 2026Article
- Proanthocyanidins as Therapeutic Agents in Inflammation-Related Skin Disorders.International journal of molecular sciences · 2025Review
- Comparative study of the photosynthetic efficiency and leaf structure of four Cotoneaster species.Scientific reports · 2024Article
- Variation in the Phenolic Profile and Antioxidant, Antihyperglycemic, and Anti-Inflammatory Activity in Leaves ofMolecules (Basel, Switzerland) · 2024Article
- Can Extracts from the Leaves and Fruits of theMolecules (Basel, Switzerland) · 2022Article
- Article
- An Overview of the GenusAntioxidants (Basel, Switzerland) · 2020Review
- Contribution of Individual Polyphenols to Antioxidant Activity ofAntioxidants (Basel, Switzerland) · 2020Article
- Polyphenol-Rich Extracts fromMolecules (Basel, Switzerland) · 2018Article
- Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba).BMC complementary and alternative medicine · 2018Article
- Qualitative and quantitative analysis of flavonoids from 12 species of Korean mulberry leaves.Journal of food science and technology · 2018Article
- Multifunctional Phytocompounds inOxidative medicine and cellular longevity · 2018Article
- Binary similarity measures for fingerprint analysis of qualitative metabolomic profiles.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Analysis of the Total Biflavonoids Extract from Selaginella doederleinii by HPLC-QTOF-MS and Its In Vitro and In Vivo Anticancer Effects.Molecules (Basel, Switzerland) · 2017Article
- Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress.Molecules (Basel, Switzerland) · 2016Review
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The antioxidant efficiency of 70% aqueous methanolic extracts from the leaves of twelve selected Cotoneaster Medik. species was evaluated using four complementary in vitro tests based on SET- (single electron transfer) and HAT-type (hydrogen atom transfer) mechanisms (DPPH, FRAP, O₂(•-) and H₂O₂ scavenging assays). The samples exhibited the dose-dependent responses in all assays with activity parameters of EC50 = 18.5-34.5 µg/mL for DPPH; 0.9-3.8 mmol Fe(2+)/g for FRAP; SC50 = 27.7-74.8 µg/mL for O₂(•-); and SC50 = 29.0-91.3 µg/mL for H₂O₂. Significant linear correlations (|r| = 0.76-0.97, p < 0.01) between activity parameters and total contents of phenolics (5.2%-15.4% GAE) and proanthocyanidins (2.1%-15.0% CYE), with weak or no effects for chlorogenic acid isomers (0.69%-2.93%) and total flavonoids (0.28%-1.40%) suggested that among the listed polyphenols, proanthocyanidins are the most important determinants of the tested activity. UHPLC-PDA-ESI-QTOF-MS analyses led to detection of 34 polyphenols, of which 10 B-type procyanidins, 5 caffeoylquinic acids and 14 flavonoids were identified. After cluster analysis of the data matrix, the leaves of Cotoneaster zabelii, C. splendens, C. bullatus, C. divaricatus, C. hjelmqvistii and C. lucidus were selected as the most promising sources of natural antioxidants, exhibiting the highest phenolic levels and antioxidant capacities, and therefore the greatest potential for pharmaceutical applications.
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