ArticleNature neuroscience2016
Silencing CA3 disrupts temporal coding in the CA1 ensemble.
Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Hippocampal theta sweeps indicate goal direction during navigation.Nature neuroscience · 2026Article
- Transformations of the spatial activity manifold convey aversive information in CA3.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- Generative emergence of non-local representations in the hippocampus.Nature communications · 2025Article
- Direct entorhinal control of CA1 temporal coding.Nature communications · 2025Article
- 40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamic gamma modulation of hippocampal place cells predominates development of theta sequences.eLife · 2025Article
- Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hippocampal place cell sequences are impaired in a rat model of Fragile X Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations.Nature communications · 2024Article
- Associative and predictive hippocampal codes support memory-guided behaviors.Science (New York, N.Y.) · 2023Article
- The medial septum controls hippocampal supra-theta oscillations.Nature communications · 2023Article
- Article
- Review
- Article
- Directional Tuning of Phase Precession Properties in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1.Cell reports · 2021Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to the place-cell rate code, hippocampal area CA1 employs a temporal code, both on the single-cell and ensemble level, to accurately represent space. Although there is clear evidence that this precise spike timing is organized by theta and gamma oscillations that are present in hippocampus, the circuit mechanisms underlying these temporal codes remain poorly understood. We found that the loss of CA3 input abolished temporal coding at the ensemble level in CA1 despite the persistence of both rate and temporal coding in individual neurons. Moreover, low gamma oscillations were present in CA1 despite the absence of CA3 input, but spikes associated with these periods carried significantly reduced spatial information. Our findings dissociate temporal coding at the single-cell (phase precession) and population (theta sequences) levels and suggest that CA3 input is crucial for temporal coordination of the CA1 ensemble code for space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.