ArticleNature chemical biology2016
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.
Article in Nature chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Zebrafish behavioral phenomics reveals functional subtypes of autism risk genes.Molecular psychiatry · 2026Article
- Sucralose Induces Neurobehavioral Alterations and Exacerbates Alzheimer's Disease-Like Phenotypes in Zebrafish Models.ACS omega · 2026Article
- Multibehavioral Phenotyping in Early-Life-Stage Zebrafish for Identifying Disruptors of Nonassociative Learning.Environmental health perspectives · 2026Article
- In Vivo Characterization of Synthetic Cannabidiol Analogs for Seizure Suppression in Zebrafish.ACS chemical neuroscience · 2026Article
- Integration of human microbiota (SIHUMIx) and zebrafish models reveals microbiome-mediated host responses to azoxystrobin.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Review
- Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals.Neurotoxicology · 2026Article
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.Communications biology · 2026Article
- NAD+ and Sirt5 restore mitochondrial bioenergetics failure and improve locomotor defects caused by sucla2 mutations.JCI insight · 2026Article
- Identification of Neuroactive Chemicals in Crude Oil-Derived Water-Accommodated Fractions.Environmental science & technology · 2026Article
- Refining methodological approaches for analysing higher-throughput locomotor behaviour, using generalized additive mixed models.Frontiers in toxicology · 2026Article
- Zebrafish as a translational filter for natural sleep modulators.Frontiers in nutrition · 2026Review
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.bioRxiv : the preprint server for biology · 2025Article
- Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals.bioRxiv : the preprint server for biology · 2025Article
- Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Disruption ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Developmental Toxicity of Haloperidol on Zebrafish (Biomedicines · 2025Article
- Behavioral Profiling in Zebrafish Identifies Insecticide-Related Compounds.Journal of agricultural and food chemistry · 2025Article
- Article
- Across preclinical and clinical platforms, approved and investigational psychiatric drugs share pathways and associate with similar molecular functions.Frontiers in drug discovery · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Many psychiatric drugs act on multiple targets and therefore require screening assays that encompass a wide target space. With sufficiently rich phenotyping and a large sampling of compounds, it should be possible to identify compounds with desired mechanisms of action on the basis of behavioral profiles alone. Although zebrafish (Danio rerio) behavior has been used to rapidly identify neuroactive compounds, it is not clear what types of behavioral assays would be necessary to identify multitarget compounds such as antipsychotics. Here we developed a battery of behavioral assays in larval zebrafish to determine whether behavioral profiles can provide sufficient phenotypic resolution to identify and classify psychiatric drugs. Using the antipsychotic drug haloperidol as a test case, we found that behavioral profiles of haloperidol-treated zebrafish could be used to identify previously uncharacterized compounds with desired antipsychotic-like activities and multitarget mechanisms of action.
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Registered trials
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