ReviewJournal of diabetes investigation2017
Pathogenesis and neuroimaging of cerebral large and small vessel disease in type 2 diabetes: A possible link between cerebral and retinal microvascular abnormalities.
Review in Journal of diabetes investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 109 citations in OpenAlex.
- Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions.Annals of medicine · 2026Review
- A web-based dynamic nomogram for individualized risk prediction of magnetic resonance imaging-defined cerebral small-vessel disease: Model development and internal validation.The Journal of international medical research · 2026Article
- Effects of Silver Nanoparticle-Loaded 18β-Glycyrrhetinic Acid on P2X7 Receptor and Endoplasmic Reticulum Stress-Mediated NLRP3 Inflammasome Activation in Testicular Tissue in an Animal Diabetes Model.Food science & nutrition · 2025Article
- Early Predictors of Remission in Acromegaly Patients after Pure Endoscopic Endonasal Transsphenoidal Surgery.Journal of neurological surgery. Part B, Skull base · 2025Article
- Diagnostic yield and therapeutic implications of vascular imaging in acute ischemic stroke: prospective and consecutive study of small vessel versus large vessel ischemia.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Article
- Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments.Open medicine (Warsaw, Poland) · 2025Review
- Transient but not chronic hyperglycemia accelerates ocular glymphatic transport.Fluids and barriers of the CNS · 2024Article
- Cerebral Small Vessel Disease Is Associated With Smaller Brain Volumes in Adults With Type 1 Diabetes.Journal of diabetes research · 2024Article
- Retinal structure and vessel density changes in cerebral small vessel disease.Frontiers in neuroscience · 2024Article
- Diffusion-weighted Imaging Detection of Acute Ischemia Brain Lesions in Spontaneous Intracerebral Hemorrhage Associated with White Matter Hyperintensities, Enlarged Perivascular Spaces and Diabetes Mellitus.Current neurovascular research · 2024Article
- Progressive reduction in basal ganglia explains and predicts cerebral structural alteration in type 2 diabetes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Clinical and Translational Imaging and Sensing of Diabetic Microangiopathy: A Narrative Review.Journal of cardiovascular development and disease · 2023Review
- Diabetic Retinopathy and Dementia Association, Beyond Diabetes Severity.American journal of ophthalmology · 2023Article
- Article
- Ophthalmic artery changes in type 2 diabetes with and without acute coronary syndrome.Journal of translational medicine · 2022Article
- Metabolic disturbances, hemoglobin A1c, and social cognition impairment in Schizophrenia spectrum disorders.Translational psychiatry · 2022Article
- Review
- Clinical and MRI features about two types of silent cerebral small-vessel disease in type-2 diabetes mellitus: a retrospective cross-sectional study in a tertiary hospital.Quantitative imaging in medicine and surgery · 2022Article
- Retinal Microvascular Caliber and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis.American journal of epidemiology · 2022Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes patients have more than double the risk of ischemic stroke compared with non-diabetic individuals, and its neuroimaging characteristics have important clinical implications. To understand the pathophysiology of ischemic stroke in diabetes, it is important to focus not only on the stroke subtype, but also on the size and location of the occlusive vessels. Specifically, ischemic stroke in diabetes patients might be attributed to both large and small vessels, and intracranial internal carotid artery disease and small infarcts of the posterior circulation often occur. An additional feature is that asymptomatic lacunar infarctions are often seen in the basal ganglia and brain stem on brain magnetic resonance imaging. In particular, cerebral small vessel disease (SVD), including lacunar infarctions, white matter lesions and cerebral microbleeds, has been shown to be associated not only with stroke incidence, but also with the development and progression of dementia and diabetic microangiopathy. However, the pathogenesis of cerebral SVD is not fully understood. In addition, data on the association between neuroimaging findings of the cerebral SVD and diabetes are limited. Recently, the clinical importance of the link between cerebral SVD and retinal microvascular abnormalities has been a topic of considerable interest. Several clinical studies have shown that retinal microvascular abnormalities are closely related to cerebral SVD, suggesting that retinal microvascular abnormalities might be pathophysiologically linked to ischemic cerebral SVD. We review the literature relating to the pathophysiology and neuroimaging of cerebrovascular disease in diabetes, and discuss the problems based on the concept of cerebral large and small vessel disease.
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