Evidence map›Paper›PMID 27239561›Full record

ArticleJCI insight2016

Molecular profiling of dilated cardiomyopathy that progresses to heart failure.

Michael A Burke, Stephen Chang, Hiroko Wakimoto, Joshua M Gorham, David A Conner, Danos C Christodoulou, Michael G Parfenov, Steve R DePalma, Seda Eminaga, Tetsuo Konno and 2 more

Open access · goldAbstract read
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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  8. G protein regulation by RGS proteins in the pathophysiology of dilated cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025
    Review
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Michael A BurkeCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Stephen ChangDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Hiroko WakimotoDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Joshua M GorhamDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
David A ConnerDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Danos C ChristodoulouDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Michael G ParfenovDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Steve R DePalmaDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Seda EminagaDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Tetsuo KonnoDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Jonathan G SeidmanDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Christine E SeidmanCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USBoston Children's Hospital · US

Funding

Defining Pathways from Gene Mutation to Heart FailureR01HL080494 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHEN, CHRISTOPHER S, SEIDMAN, CHRISTINE E · 2005 to 2024
$9.4M
Molecular Signaling in Hypertrophic CardiomyopathyR01HL084553 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2007 to 2022
$5.9M
Harvard Regional Clinical Center of the NHLBI Heart Failure NetworkU10HL110337 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GIVERTZ, MICHAEL M, LEWIS, GREGORY DYER · 2012 to 2018
$3.5M
NHLBI NIH HHS R01 HL080494NHLBI NIH HHS R01 HL084553NHLBI NIH HHS U10 HL110337
6 · The paper itself

Abstract

Dilated cardiomyopathy (DCM) is defined by progressive functional and structural changes. We performed RNA-seq at different stages of disease to define molecular signaling in the progression from pre-DCM hearts to DCM and overt heart failure (HF) using a genetic model of DCM (phospholamban missense mutation, PLN

Identifiers

PMID27239561
PMCPMC4882118
OpenAlexW2345655181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.