Evidence map›Paper›PMID 27239558›Full record

ArticleNPJ Parkinson's disease

Fatigue in Parkinson's disease: report from a mutidisciplinary symposium.

Joseph H Friedman, James C Beck, Kelvin L Chou, Gracia Clark, Christopher P Fagundes, Christopher G Goetz, Karen Herlofson, Benzi Kluger, Lauren B Krupp, Anthony E Lang and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03446807 (Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism), which is not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03446807 phase2withdrawnnot on this map

Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism

TypeinterventionalSponsorLoma Linda UniversityRan2021 to 2023Enrolled0ConditionsParkinson Disease, Multiple System Atrophy, Progressive Supranuclear PalsyArmsDroxidopa, Placebo Oral Tablet
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  7. Research progress of chronic fatigue in neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 3 countries.

Joseph H FriedmanMovement Disorders Program, Butler Hospital, Province, RI, USA; Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.
James C BeckParkinson's Disease Foundation, New York, NY, USA.
Kelvin L ChouDepartment of Neurology, University of Michigan Health System, Ann Arbor, MI, USA; Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI, USA.
Gracia ClarkParkinson's Disease Foundation, New York, NY, USA.
Christopher P FagundesDepartment of Psychology, Rice University, M.D. Anderson Cancer Center, Houston, TX, USA; Department of Health Disparities, Houston, TX, USA.
Christopher G GoetzDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Karen HerlofsonDepartment of Neurology, Sorlandet Hospital, Arendal, Norway.
Benzi KlugerDepartment of Neurology, University of Colorado Anschutz Campus, Aurora, CO, USA.
Lauren B KruppDepartment of Neurology, Stony Brook University Medical Center, Stony Brook, NY, USA.
Anthony E LangToronto Western Hospital, Morton and Gloria Shulman Movement Disorders Clinic and Edmond J Safra Program in Parkinson's Disease, Toronto, ON, Canada.
Jao-Shin LouUniversity of North Dakota School of Medicine and Health Services, Sanford Health, Grand Forks, ND, USA.
Laura MarshDepartment of Psychiatry, Baylor College of Medicine, Mental Health Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA; Department of Neurology, Baylor College of Medicine, Mental Health Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Anne NewbouldParkinson's Disease Foundation, New York, NY, USA.
Daniel WeintraubDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Parkinson's Foundation · USButler Hospital · USMichael E. DeBakey VA Medical Center · USRice University · USRush University Medical Center · USSørlandet Hospital Arendal · NOStony Brook University Hospital · USToronto Western Hospital · CAUniversity of Colorado Anschutz Medical Campus · USUniversity of Michigan · USUniversity of North Dakota · USUniversity of Pennsylvania · US

Funding

Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Michigan Parkinson's Disease Clinical CenterU10NS044504 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHOU, KELVIN L · 2002 to 2013
$785k
NINDS NIH HHS P50 NS091856NINDS NIH HHS U10 NS044504
6 · The paper itself

Abstract

Fatigue is a severe problem for many people living with Parkinson's disease (PD). Best estimates suggest that more than 50% of patients experience this debilitating symptom. Little is known about its etiology or treatment, making the understanding of fatigue a true unmet need. As part of the Parkinson's Disease Foundation Community Choice Research Program, patients, caregivers, and scientists attended a symposium on fatigue on 16 and 17 October 2014. We present a summary of that meeting, reviewing what is known about the diagnosis and treatment of fatigue, its physiology, and what we might learn from multiple sclerosis (MS), depression, and cancer-disorders in which fatigue figures prominently too. We conclude with focused recommendations to enhance our understanding and treatment of this prominent problem in PD.

Identifiers

PMID27239558
PMCPMC4883681
OpenAlexW2462372318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.