Evidence map›Paper›PMID 27239552›Full record

ArticleAdvances in medicine2016

Osteogenic Potential of Multipotent Adult Progenitor Cells for Calvaria Bone Regeneration.

Dong Joon Lee, Yonsil Park, Wei-Shou Hu, Ching-Chang Ko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dong Joon LeeOral and Craniofacial Health Sciences Research, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7455, USA.
Yonsil ParkDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455-0132, USA.
Wei-Shou HuDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455-0132, USA.
Ching-Chang KoOral and Craniofacial Health Sciences Research, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7455, USA; Department of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7454, USA.

Funding

Engineering novel bio-inspired materials for stem-cell mediated bone regenerationR01DE022816 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KO, CHING-CHANG · 2014 to 2018
$2.0M
Engineering a new biomaterial for stem-cell mediated bone regenerationK08DE018695 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KO, CHING-CHANG · 2008 to 2011
$507k
NIDCR NIH HHS K08 DE018695NIDCR NIH HHS R01 DE022816
6 · The paper itself

Abstract

Osteogenic cells derived from rat multipotent adult progenitor cells (rMAPCs) were investigated for their potential use in bone regeneration. rMAPCs are adult stem cells derived from bone marrow that have a high proliferation capacity and the differentiation potential to multiple lineages. They may also offer immunomodulatory properties favorable for applications for regenerative medicine. rMAPCs were cultivated as single cells or as 3D aggregates in osteogenic media for up to 38 days, and their differentiation to bone lineage was then assessed by immunostaining of osteocalcin and collagen type I and by mineralization assays. The capability of rMAPCs in facilitating bone regeneration was evaluated in vivo by the direct implantation of multipotent adult progenitor cell (MAPC) aggregates in rat calvarial defects. Bone regeneration was examined radiographically, histologically, and histomorphometrically. Results showed that rMAPCs successfully differentiated into osteogenic lineage by demonstrating mineralized extracellular matrix formation in vitro and induced new bone formation by the effect of rMAPC aggregates in vivo. These outcomes confirm that rMAPCs have a good osteogenic potential and provide insights into rMAPCs as a novel adult stem cell source for bone regeneration.

Identifiers

PMID27239552
PMCPMC4864565

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.