ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2016
Repeated systemic inflammation was associated with cognitive deficits in older Britons.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026Review
- Cerebral Neurodegeneration and Cognitive Impairment in Patients on Maintenance Hemodialysis: the Role of Neuroglia and Associated Factors (Review).Sovremennye tekhnologii v meditsine · 2026Review
- The effect of peer victimisation on cognitive development in childhood: evidence for mediation via inflammation.Social psychiatry and psychiatric epidemiology · 2025Article
- Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Chronic inflammation is associated with worsening working memory performance: Preliminary evidence from a diverse, longitudinal cohort of adolescents and young adults.Psychoneuroendocrinology · 2024Article
- C-Reactive protein and cognition: Mediation analyses with brain morphology in the UK Biobank.Brain, behavior, & immunity - health · 2023Article
- Article
- The Future of Precision Medicine in the Cure of Alzheimer's Disease.Biomedicines · 2023Review
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- Trajectories of Cognitive Impairment in Adults Bearing Vascular Risk Factors, with or without Diagnosis of Mild Cognitive Impairment: Findings from a Longitudinal Study Assessing Executive Functions, Memory, and Social Cognition.Diagnostics (Basel, Switzerland) · 2022Article
- The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy.BMC endocrine disorders · 2022Observational
- Acute versus chronic inflammatory markers and cognition in older black adults: Results from the Minority Aging Research Study.Brain, behavior, and immunity · 2022Article
- Effects of anFrontiers in aging neuroscience · 2021Article
- Fibrinogen Levels and Cognitive Profile Differences in Patients with Mild Cognitive Impairment.Dementia and geriatric cognitive disorders · 2020Article
- High levels of plasma fibrinogen are related to post-stroke cognitive impairment.Brain and behavior · 2019Article
- Systemic Inflammation Is Associated With Longitudinal Changes in Cognitive Performance Among Urban Adults.Frontiers in aging neuroscience · 2018Article
- PRECISION MEDICINE - The Golden Gate for Detection, Treatment and Prevention of Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2016Article
- Introduction to special issue on Advances in blood-based biomarkers of Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016Article
- National Economic Development Status May Affect the Association between Central Adiposity and Cognition in Older Adults.PloS one · 2016Article
- The mediating role of low-grade inflammation on the prospective association between sleep and cognitive function in older men and women: 8-year follow-up from the English Longitudinal Study of Ageing.Archives of gerontology and geriatricsArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
introductionThe relationship of C-reactive protein (CRP) to cognition in the older old group (≥75 years) has recently been found positive on both sides of the Atlantic. We hypothesized that higher levels of CRP and fibrinogen are related to worse episodic memory throughout later life (≥50 years).
methodsData are drawn from older Britons free of dementias in the English Longitudinal Study of Aging 2004-2013. We applied growth trajectory models to repeated observations of episodic memory, CRP, and fibrinogen levels (and sociodemographic confounders). We accounted for practice effects in repeated tests of cognition.
resultsHigher levels of both inflammatory markers were associated with worse episodic memory, where a fibrinogen effect is evident throughout later life (coefficient -0.154; 95% confidence interval [CI] -0.254 to -0.054). Most importantly, the CRP effect is strongly negative among the older old group (coefficient -0.179; CI -0.320 to -0.038). DISCUSSION: Higher levels of fibrinogen are detrimental to older people's cognition, and among the older old, raised CRP levels are comparably deleterious. Repeated measures of inflammation can be considered in clinical practice as part of a response to the challenge of dementias.
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