ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2016
Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Cardiometabolic medication exposures and cognitive outcomes in Alzheimer's disease.Age and ageing · 2026Article
- The Use of Antihypertensive Medication and In Vivo Alzheimer's Disease Pathology.Annals of neurology · 2025Article
- Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Angiotensin Receptor Blockers and Cognition: a Scoping Review.Current hypertension reports · 2024Article
- Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Hypertension, Neurovascular Dysfunction, and Cognitive Impairment.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Microglia and Cholesterol Handling: Implications for Alzheimer's Disease.Biomedicines · 2022Review
- Neuroinflammation: A Possible Link Between Chronic Vascular Disorders and Neurodegenerative Diseases.Frontiers in aging neuroscience · 2022Review
- Statistical Parametric Mapping in Amyloid Positron Emission Tomography.Frontiers in aging neuroscience · 2022Article
- Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide.Frontiers in aging neuroscience · 2022Article
- Blood-Brain Barrier Crossing Renin-Angiotensin System Drugs: Considerations for Dementia and Cognitive Decline.Hypertension (Dallas, Tex. : 1979) · 2021Article
- The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status.Alzheimer's research & therapy · 2021Article
- Association of Vascular Risk Factors With β-Amyloid Peptide and Tau Burdens in Cognitively Unimpaired Individuals and Its Interaction With Vascular Medication Use.JAMA network open · 2020Article
- Antihypertensive medications ameliorate Alzheimer's disease pathology by slowing its propagation.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Statins and Cognitive Impairment: Not a Culprit, Protective in Some?Journal of the American College of Cardiology · 2019Article
- Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults.Journal of Alzheimer's disease : JAD · 2018Article
- Metabolic Syndrome and Amyloid Accumulation in the Aging Brain.Journal of Alzheimer's disease : JAD · 2018Article
- Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes.Alzheimer's & dementia (Amsterdam, Netherlands) · 2017Article
- Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis.Alzheimer's & dementia (Amsterdam, Netherlands) · 2017Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionHypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition.
methodsA cross-sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta-blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition.
resultsThe use of ARBs (β = -.15, P = .044) and diuretics (β = -.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P < .001) and statins (β = .23, P = .004) were related to greater amyloid deposition. Overweight and/or obese women had more cortical amyloid than their peers. DISCUSSION: Prospective studies should confirm effects of drugs and increased body weight on amyloid accumulation and establish whether they translate into measurable clinical outcomes. Women may be more susceptible to harmful effects of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.