ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2015
A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ERP and qEEG Measures Collected in Outpatient Settings as Indices of Disease Progression in Alzheimer's Disease (AD)
Quantitative EEG for Assessment of Mild Cognitive Impairment Associated With Preclinical Alzheimer's Disease - Evidence for Amyloid Indication Study
Establishing Normative Values for Event Related Potentials (ERPs) and Quantitative EEG (QEEG) in Adult, Healthy Volunteers
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Investigating Auditory Electrophysiological Measures of Participants with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Event-Related Potential Studies.Journal of Alzheimer's disease : JAD · 2021Pooled it
- Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Positive Modulator of HGF/MET, Fosgonimeton, in Healthy Volunteers and Subjects with Alzheimer's Disease: Randomized, Placebo-Controlled, Double-Blind, Phase I Clinical Trial.Journal of Alzheimer's disease : JAD · 2022Trial
- AI-enabled digital phenotyping for Alzheimer's disease: a review of multimodal sensor integration and symptom trajectories.Alzheimer's research & therapy · 2026Review
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Evaluation of health effect on workers exposed to methyl bromide with prefrontal event-related potential.PloS one · 2025Article
- Biomarker and neuropsychological correlates of the N400 event-related potential in Alzheimer's disease.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
- Applications of event-related potentials in Alzheimer's disease: a systematic review and analysis.Frontiers in aging neuroscience · 2025Review
- Hearing Loss and Cognitive Decline in the Aging Population: Emerging Perspectives in Audiology.Audiology research · 2024Article
- Prefrontal intra-individual ERP variability and its asymmetry: exploring its biomarker potential in mild cognitive impairment.Alzheimer's research & therapy · 2024Article
- The Use of Event Related Potentials to Predict Amyloid PET Status Among Patients from a Memory Disorders Clinic.Journal of Alzheimer's disease : JAD · 2024Article
- Experimental Medicine Approaches in Early-Phase CNS Drug Development.Advances in neurobiology · 2023Article
- Prefrontal event-related potential markers in association with mild cognitive impairment.Frontiers in aging neuroscience · 2023Article
- Recent advances in understanding Alzheimer's Disease: diagnosis and management strategies.Faculty reviews · 2023Review
- Exploring electrophysiological markers of auditory predictive processes and pathological ageing in adults with Down's syndrome.The European journal of neuroscience · 2022Article
- New approaches for the quantification and targeting of noradrenergic dysfunction in Alzheimer's disease.Annals of clinical and translational neurology · 2022Review
- The influence of different types of auditory change on processes associated with the switching of attention in older adults and people with mild cognitive impairment.Neuroimage. Reports · 2022Article
- Differentiation of Subjective Cognitive Decline, Mild Cognitive Impairment, and Dementia Using qEEG/ERP-Based Cognitive Testing and Volumetric MRI in an Outpatient Specialty Memory Clinic.Journal of Alzheimer's disease : JAD · 2022Article
- Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential.Neural plasticity · 2022Review
- Critical Dynamics in Spontaneous Resting-State Oscillations Are Associated With the Attention-Related P300 ERP in a Go/Nogo Task.Frontiers in neuroscience · 2021Article
- Event-Related Potential Measures of the Passive Processing of Rapidly and Slowly Presented Auditory Stimuli in MCI.Frontiers in aging neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
introductionWe investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD).
methodsA total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm.
resultsSubjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test. DISCUSSION: Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.