Evidence map›Paper›PMID 27239455›Full record

ArticleOcular oncology and pathology2016

Detection and Intraretinal Localization of an 'Invisible' Retinoblastoma Using Optical Coherence Tomography.

Jesse L Berry, David Cobrinik, Jonathan W Kim

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular oncology and pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Factors correlated to different patterns of regression of retinoblastoma defined by optical coherence tomography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Review
  4. Panretinal Optical Coherence Tomography.IEEE transactions on medical imaging · 2023
    Article
  5. Article
  6. Article
  7. Tumor Environment of Retinoblastoma, Intraocular Cancer.Advances in experimental medicine and biology · 2020
    Article
  8. Review
  9. Article
  10. Review
  11. Retinoblastoma, the visible CNS tumor: A review.Journal of neuroscience research · 2019
    Review
  12. Article
  13. Optical coherence tomography imaging of the peripheral retina.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jesse L BerryThe Vision Center at Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, Calif., USA.
David CobrinikThe Vision Center at Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, Calif., USA.
Jonathan W KimThe Vision Center at Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, Calif., USA.
University of Southern California · USChildren's Hospital of Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report the use of handheld spectral-domain optical coherence tomography (HHSD OCT) to identify and define the intraretinal location of a small retinoblastoma that was not detectable by indirect ophthalmoscopy.

methodsThis is a retrospective case report of a tumor identified with HHSD OCT in a single patient.

resultsA 7-week-old male was diagnosed with unilateral group E retinoblastoma in the right eye. An enucleation was completed successfully with histopathologic confirmation of the diagnosis. The normal left eye was monitored for the development of retinoblastoma, and 10 weeks after diagnosis, three new small retinoblastomas were noted in the posterior pole. Identification of the smallest of the three tumors was facilitated by HHSD OCT; it was adjacent to the optic nerve head, and involved the outer nuclear layer, outer plexiform layer, and inner nuclear layer, with the inner retina draping over the tumor.

conclusionHHSD OCT can aid the ocular oncologist in the identification of very small retinoblastomas before they are visible to the eye, which allows for earlier and potentially vision-sparing treatment of these lesions. Additionally, the ability to identify these very small tumors and to localize them anatomically within the retinal layers may aid in our understanding of retinoblastoma tumorigenesis.

Indexed as

Ocular oncologyOptical coherence tomographyRetinoblastoma

Identifiers

PMID27239455
PMCPMC4881267
OpenAlexW2287861553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.