ArticleJournal of cachexia, sarcopenia and muscle2016
Improvement of skeletal muscle performance in ageing by the metabolic modulator Trimetazidine.
Article in Journal of cachexia, sarcopenia and muscle, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Integrative analysis of RNA-seq and Ribo-seq reveals that lncRNA regulates chicken myogenesis through encoding peptide.Journal of animal science and biotechnology · 2026Article
- Associations of Muscle Mass, Strength, and Power with Falls Among Active Community-Dwelling Older Adults.Diagnostics (Basel, Switzerland) · 2026Article
- Trimetazidine stimulates intracellular CaScientific reports · 2025Article
- Trimetazidine Improves Mitochondrial Dysfunction in SOD1International journal of molecular sciences · 2024Article
- PaSTe. Blockade of the Lipid Phenotype of Prostate Cancer as Metabolic Therapy: A Theoretical Proposal.Current medicinal chemistry · 2024Review
- Trimetazidine improves angiogenesis and tissue perfusion in ischemic rat skeletal muscle.Frontiers in pharmacology · 2024Article
- Article
- Relationship between muscle mass and muscle strength with physical performance in older adults: A systematic review.SAGE open medicine · 2023Review
- Ranolazine Counteracts Strength Impairment and Oxidative Stress in Aged Sarcopenic Mice.Metabolites · 2022Article
- Long noncoding RNA ZFP36L2-AS functions as a metabolic modulator to regulate muscle development.Cell death & disease · 2022Article
- Camptothecin effectively treats obesity in mice through GDF15 induction.PLoS biology · 2022Article
- Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.Scientific reports · 2021Article
- Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis.Cell death discovery · 2021Article
- Skeletal Muscle Metabolism: Origin or Prognostic Factor for Amyotrophic Lateral Sclerosis (ALS) Development?Cells · 2021Review
- Animal models of sarcopenia.Aging cell · 2020Review
- Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.Cell metabolism · 2020Article
- Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice.PLoS biology · 2020Article
- Thyroid Hormone Protects from Fasting-Induced Skeletal Muscle Atrophy by Promoting Metabolic Adaptation.International journal of molecular sciences · 2019Article
- Metabolic Reprogramming Promotes Myogenesis During Aging.Frontiers in physiology · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe loss of muscle mass (sarcopenia) and the associated reduced muscle strength are key limiting factors for elderly people's quality of life. Improving muscle performance does not necessarily correlate with increasing muscle mass. In fact, particularly in the elderly, the main explanation for muscle weakness is a reduction of muscle quality rather than a loss of muscle mass, and the main goal to be achieved is to increase muscle strength. The effectiveness of Trimetazidine (TMZ) in preventing muscle functional impairment during ageing was assessed in our laboratory.
methodsAged mice received TMZ or vehicle for 12 consecutive days. Muscle function was evaluated at the end of the treatment by a grip test as well as by an inverted screen test at 0, 5, 7 and 12 days of TMZ treatment. After sacrifice, muscles were stored for myofiber cross-sectional area assessment and myosin heavy chain expression evaluation by western blotting.
resultsChronic TMZ treatment does not affect the mass of both gastrocnemius and tibialis anterior muscles, while it significantly increases muscle strength. Indeed, both latency to fall and grip force are markedly enhanced in TMZ-treated versus untreated mice. In addition, TMZ administration results in higher expression of slow myosin heavy chain isoform and increased number of small-sized myofibers.
conclusionsWe report here some data showing that the modulation of skeletal muscle metabolism by TMZ increases muscle strength in aged mice. Reprogramming metabolism might therefore be a strategy worth to be further investigated in view of improving muscle performance in the elderly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.