Evidence map›Paper›PMID 27239296›Full record

ReviewF1000Research2016

Recent advances in metabolic and bariatric surgery.

Vance L Albaugh, C Robb Flynn, Robyn A Tamboli, Naji N Abumrad

Abstract readReview
In one paragraph

Review in F1000Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Recent advances in the mechanisms underlying the beneficial effects of bariatric and metabolic surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Surgical treatment of obesity.F1000Research · 2018
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vance L AlbaughDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.
C Robb FlynnDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.
Robyn A TamboliDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.
Naji N AbumradDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, 37232, USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Roland W Stein · 2012 to 2026
$29.3M
TRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI ELASY, TOM A · 1986 to 2011
$28.1M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
Role of the Omentum in the Treatment of Morbid ObesityR01DK070860 · NIDDK · VANDERBILT UNIVERSITY · PI ABUMRAD, NAJI N · 2005 to 2009
$4.2M
RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue AxisR01DK091748 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ABUMRAD, NAJI N · 2011 to 2015
$3.0M
Bile Diversion: A Simple and Effective Method of Treating ObesityR01DK105847 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ABUMRAD, NAJI N, FLYNN, CHARLES R · 2015 to 2019
$1.8M
Role of the foregut in nutrient metabolism in lean and obese humansR01DK100431 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ABUMRAD, NAJI N · 2014 to 2017
$1.4M
Molecular and Cellular Basis for the Efficacy of Bariatric SurgeryR24DK096527 · NIDDK · VANDERBILT UNIVERSITY · PI ABUMRAD, NAJI N, CONE, ROGER D. · 2013 to 2014
$1.2M
Mechanisms of Bile Acid Signaling and Metabolism following Gastric BypassF32DK103474 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALBAUGH, VANCE L · 2014 to 2016
$177k
NCATS NIH HHS UL1 TR002243NCRR NIH HHS UL1 RR024975NIDDK NIH HHS F32 DK103474NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS P60 DK020593NIDDK NIH HHS R01 DK070860NIDDK NIH HHS R01 DK091748NIDDK NIH HHS R01 DK100431NIDDK NIH HHS R01 DK105847NIDDK NIH HHS R24 DK096527NIDDK NIH HHS U2C DK059637
6 · The paper itself

Abstract

Obesity and its associated medical conditions continue to increase and add significant burden to patients, as well as health-care systems, worldwide. Bariatric surgery is the most effective treatment for severe obesity and its comorbidities, and resolution of diabetes is weight loss-independent in the case of some operations. Although these weight-independent effects are frequently described clinically, the mechanisms behind them are not well understood and remain an intense area of focus in the growing field of metabolic and bariatric surgery. Perceptions of the mechanisms responsible for the beneficial metabolic effects of metabolic/bariatric operations have shifted from being mostly restrictive and malabsorption over the last 10 to 15 years to being more neuro-hormonal in origin. In this review, we describe recent basic and clinical findings of the major clinical procedures (adjustable gastric banding, vertical sleeve gastrectomy, Roux-en-Y gastric bypass, and biliopancreatic diversion) as well as other experimental procedures (ileal interposition and bile diversion) that recapitulate many of the metabolic effects of these complex operations in a simpler fashion. As the role of bile acids and the gut microbiome on metabolism is becoming increasingly well described, their potential roles in these improvements following metabolic surgery are becoming better appreciated. Bile acid and gut microbiome changes, in light of recent developments, are discussed in the context of these surgical procedures, as well as their implications for future study.

Indexed as

adjustable gastric bandingBariatric surgerybile diversionbiliopancreatic diversionileal interpositionMetabolic surgeryMorbid obesityRoux-en-Y gastric bypassvertical sleeve gastrectomy

Identifiers

PMID27239296
PMCPMC4879937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.