Evidence map›Paper›PMID 27239289›Full record

ReviewF1000Research2016

Central control of body temperature.

Shaun F Morrison

Open access · goldAbstract readReview
In one paragraph

Review in F1000Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it, 210 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Homeostatic medicine: a strategy for exploring health and disease.Current medicine (Cham, Switzerland) · 2022
    Review
  18. Article
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Shaun F MorrisonDepartment of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA.
Oregon Health & Science University · US

Funding

Central Sympathetic Regulation of Thermogenesis in FeverR01NS040987 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, SHAUN F · 2001 to 2013
$3.7M
Central inhibitory regulation of brown adipose thermogenesisR01NS091066 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORRISON, SHAUN F · 2015 to 2018
$1.3M
NINDS NIH HHS R01 NS040987NINDS NIH HHS R01 NS091066
6 · The paper itself

Abstract

Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. This review summarizes the central nervous system circuit mechanisms controlling the principal thermoeffectors for body temperature regulation: cutaneous vasoconstriction regulating heat loss and shivering and brown adipose tissue for thermogenesis. The activation of these thermoeffectors is regulated by parallel but distinct efferent pathways within the central nervous system that share a common peripheral thermal sensory input. The model for the neural circuit mechanism underlying central thermoregulatory control provides a useful platform for further understanding of the functional organization of central thermoregulation, for elucidating the hypothalamic circuitry and neurotransmitters involved in body temperature regulation, and for the discovery of novel therapeutic approaches to modulating body temperature and energy homeostasis.

Indexed as

Brown adipose tissuecutaneous vasoconstrictiondorsomedial hypothalamusfeverobesitypreoptic hypothalamusrostral raphe pallidusshiversympathetic nerve activitytherapeutic hypothermiathermogenesis

Identifiers

PMID27239289
PMCPMC4870994
OpenAlexW2354621795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.