Evidence map›Paper›PMID 27239119›Full record

ArticleWorld journal of gastroenterology2016

Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease.

Anita Kiani, Vanessa Brun, Fabrice Lainé, Bruno Turlin, Jeff Morcet, Sophie Michalak, Antonia Le Gruyer, Ludivine Legros, Edouard Bardou-Jacquet, Yves Gandon and 1 more

Registry-linked trialOpen access · hybridAbstract readComparative StudyEvaluation Study
In one paragraph

Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01789008 (Interest of Transient Elastography in the Determination of Advanced Fibrosis in Alcoholic Liver Didease in Alcoholic Patients in Weaning.), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01789008 nacompletednot on this map

Interest of Transient Elastography in the Determination of Advanced Fibrosis in Alcoholic Liver Didease in Alcoholic Patients in Weaning.

TypeinterventionalSponsorRennes University HospitalRan2013 to 2017Enrolled300ConditionsAlcoholism, Liver Disease, Liver FibrosisArmsDetermination of Advanced Fibrosis in Alcoholic Liver Disease
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  12. Principles of ultrasound elastography.Abdominal radiology (New York) · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Anita KianiAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Vanessa BrunAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Fabrice LainéAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Bruno TurlinAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Jeff MorcetAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Sophie MichalakAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Antonia Le GruyerAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Ludivine LegrosAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Edouard Bardou-JacquetAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Yves GandonAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Romain MoirandAnita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
Centre Hospitalier Universitaire de Rennes · FRFoie, Métabolisme, Cancer · FRCIC Rennes · FRLaboratoire de Génétique Cellulaire · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the performance of elastography by ultrasound with acoustic radiation force impulse (ARFI) in determining fibrosis stage in patients with alcoholic liver disease (ALD) undergoing alcoholic detoxification in relation to biopsy.

methodsEighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy on the same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each patient.

resultsSixty-nine males and thirteen females (one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4% (0.70-0.95) and 83.3% (0.73-0.94) (AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4% (0.64-1.00) and 78.5% (0.69-0.89) (AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3% (0.78-1.00] and 81.6% (0.72-0.90) (AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/s.

conclusionARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification.

Indexed as

Elasticity Imaging TechniquesAdultArea Under CurveBiopsyFemaleHumansLiverLiver Cirrhosis, AlcoholicMaleMiddle AgedPredictive Value of TestsProspective StudiesReproducibility of ResultsROC CurveSeverity of Illness IndexAcoustic radiation force impulseAlcoholic liver diseaseElastographyFibrosisNon-invasive

Identifiers

PMID27239119
PMCPMC4873885
OpenAlexW2406224943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.