Evidence map›Paper›PMID 27238356›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2016

Maternal age and asthma in Latino populations.

Z Abid, S S Oh, D Hu, S Sen, S Huntsman, C Eng, H J Farber, W Rodriguez-Cintron, J R Rodriguez-Santana, D Serebrisky and 8 more

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Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Z AbidDivision of Allergy-Immunology, Department of Medicine, Northwestern University, Chicago, IL, USA.
S S OhDepartment of Medicine, University of California, San Francisco, CA, USA.
D HuDepartment of Medicine, University of California, San Francisco, CA, USA.
S SenDepartment of Biostatistics, University of California, San Francisco, CA, USA.
S HuntsmanDepartment of Medicine, University of California, San Francisco, CA, USA.
C EngDepartment of Medicine, University of California, San Francisco, CA, USA.
H J FarberDepartment of Pediatrics, Section of Pulmonology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
W Rodriguez-CintronVeterans Caribbean Health Care System, San Juan, PR, USA.
J R Rodriguez-SantanaCentro de Neumologia Pediatrica, CSP, San Juan, PR, USA.
D SerebriskyPediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY, USA.
P C AvilaDivision of Allergy-Immunology, Department of Medicine, Northwestern University, Chicago, IL, USA.
S M ThyneDepartment of Pediatrics, University of California, San Francisco, CA, USA.
K-Y A KimDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
L N BorrellDepartment of Health Sciences, Lehman College, CUNY, New York, NY, USA.
L K WilliamsDepartment of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
M A SeiboldCenter for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.
E G BurchardDepartment of Medicine, University of California, San Francisco, CA, USA.
R KumarDivision of Allergy-Immunology, Department of Pediatrics, Northwestern University, Chicago, IL, USA. rkumar@luriechildrens.org.

Funding

Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1M
ZOLENDRONIC ACID IN CHILDREN W/ SEVERE OSTEOGENESIS IMPERFECTAM01RR000188 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI PLON, SHARON E. · 1985 to 2011
$30.6M
New Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1M
WELFARE REFORM AND THE PERINATAL HEALTH OF IMMIGRANTSM01RR000083 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$21.1M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
Postdoctoral training in tobacco controlR25CA113710 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLANTZ, STANTON ARNOLD · 2006 to 2015
$5.4M
Whole Genome Analyses for Asthma in Latino PopulationsR01HL088133 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$3.8M
Genes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8M
Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed PopulationsR01HL118267 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2014 to 2017
$2.9M
Postdoctoral training in tobacco controlT32CA113710 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2016 to 2020
$2.6M
NCI NIH HHS R25 CA113710NCI NIH HHS T32 CA113710NCRR NIH HHS M01 RR000083NCRR NIH HHS M01 RR000188NHLBI NIH HHS K23 HL004464NHLBI NIH HHS K23 HL093023NHLBI NIH HHS R01 HL078885NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL118267NIAID NIH HHS U19 AI077439NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIMHD NIH HHS L32 MD000659NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
6 · The paper itself

Abstract

backgroundYounger maternal age at birth is associated with increased risk of asthma in offspring in European descent populations, but has not been studied in Latino populations.

objectivesWe sought to examine the relationship between maternal age at birth and prevalence of asthma in a nationwide study of Latino children.

methodsWe included 3473 Latino children aged 8-21 years (1696 subjects with physician-diagnosed asthma and 1777 healthy controls) from five US centres and Puerto Rico recruited from July 2008 through November 2011. We used multiple logistic regression models to examine the effect of maternal age at birth on asthma in offspring overall and in analyses stratified by ethnic subgroup (Mexican American, Puerto Rican and other Latino). Secondary analyses evaluated the effects of siblings, acculturation and income on this relationship.

resultsMaternal age < 20 years was significantly associated with decreased odds of asthma in offspring, independent of other risk factors (OR = 0.73, 95% CI: 0.57-0.93). In subgroup analyses, the protective effect of younger maternal age was observed only in Mexican Americans (OR = 0.53, 95% CI: 0.36, 0.79). In Puerto Ricans, older maternal age was associated with decreased odds of asthma (OR = 0.65, 95% CI: 0.44-0.97). In further stratified models, the protective effect of younger maternal age in Mexican Americans was seen only in children without older siblings (OR = 0.44, 95% CI: 0.23-0.81). CONCLUSION AND CLINICAL RELEVANCE: In contrast to European descent populations, younger maternal age was associated with decreased odds of asthma in offspring in Mexican American women. Asthma is common in urban minority populations but the factors underlying the varying prevalence among different Latino ethnicities in the United States is not well understood. Maternal age represents one factor that may help to explain this variability.

Indexed as

Hispanic or LatinoMaternal AgeAdolescentAsthmaCase-Control StudiesChildFemaleHumansMalePopulation SurveillanceRisk FactorsUnited StatesYoung Adultasthmaprenatal exposures

Identifiers

PMID27238356
PMCPMC5770153

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