ArticleCurrent biology : CB2016
Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.
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Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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111citing papers in PubMed
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Who cites it
111 citing papers in PubMed, 201 citations in OpenAlex.
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- Decoding plant volatile stress signals across scales: from molecular responses to ecosystem dynamics.Frontiers in plant science · 2026Review
- The complete mitochondrial genome sequence of the saprotrophic filamentous fungusMitochondrial DNA. Part B, Resources · 2026Article
- A BRCT domain-containing protein induced in early phagocytosis plays a crucial role in the pathogenesis of the mucoralean Rhizopus microsporus.PLoS pathogens · 2026Article
- Calcium starvation leads to strain-specific gene regulation of lipid and carotenoid production in Mucor circinelloides.G3 (Bethesda, Md.) · 2025Article
- Multidrug efflux pumps and innate azole resistance of Mucor lusitanicus.The Journal of antimicrobial chemotherapy · 2025Article
- How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology.Microbiology and molecular biology reviews : MMBR · 2025Review
- Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage.Molecular systems biology · 2025Article
- Independent evolution of betulin biosynthesis in Inonotus obliquus.Scientific reports · 2025Article
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- Article
- Light reception of Phycomyces revisited: several white collar proteins confer blue- and red-light sensitivity and control dynamic range and adaptation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Review
- Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales.Nature communications · 2024Article
- Extreme overall mushroom genome expansion in Mycena s.s. irrespective of plant hosts or substrate specializations.Cell genomics · 2024Article
- Evolutionary history of arbuscular mycorrhizal fungi and genomic signatures of obligate symbiosis.BMC genomics · 2024Article
- Transcription Factors Tec1 and Tec2 Play Key Roles in the Hyphal Growth and Virulence of Mucor lusitanicus Through Increased Mitochondrial Oxidative Metabolism.Journal of microbiology (Seoul, Korea) · 2023Article
- On being a Hydra with, and without, a nervous system: what do neurons add?Animal cognition · 2023Review
- Light regulation of secondary metabolism in fungi.Journal of biological engineering · 2023Review
51 more citing papers are in PubMed but not listed here.
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Authors and funding
72 authors at 20 institutions in 13 countries.
Luis M CorrochanoDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain. Electronic address: corrochano@us.es.
Alan KuoUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Marina Marcet-HoubenCentre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain.
Silvia PolainoSchool of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA.
Asaf SalamovUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
José M Villalobos-EscobedoLaboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.
Jane GrimwoodUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.
M Isabel ÁlvarezDepartamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
Javier AvalosDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Diane BauerUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Ernesto P BenitoDepartamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.
Isabelle BenoitCBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
Gertraud BurgerUniversite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.
Lola P CaminoDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
David CánovasDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Enrique Cerdá-OlmedoDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Jan-Fang ChengUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Angel DomínguezDepartamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
Marek EliášDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00 Ostrava, Czech Republic.
Arturo P EslavaDepartamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
Fabian GlaserLokey Interdisciplinary Center for Life Sciences and Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
Gabriel GutiérrezDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
Bernard HenrissatCentre National de la Recherche Scientifique (CNRS), UMR7257, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Enrique A IturriagaDepartamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
B Franz LangUniversite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.
José L LavínGenome Analysis Platform, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Bizkaia, Spain.
Soo Chan LeeDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
Wenjun LiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.
Erika LindquistUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Sergio López-GarcíaDepartamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.
Eva M LuqueDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Ana T MarcosDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Joel MartinUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Kevin McCluskeyDepartment of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, KS 66506, USA.
Humberto R MedinaDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Alejandro Miralles-DuránDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Atsushi MiyazakiDepartment of Biological Sciences, Faculty of Science and Engineering, Ishinomaki Senshu University, Ishinomaki 986-8580, Japan.
Elisa Muñoz-TorresDepartamento de Biología Celular y Patología, Facultad de Medicina, Universidad de Salamanca, Avenida Campus Miguel de Unamuno, 37007 Salamanca, Spain.
José A OguizaDepartment of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.
Robin A OhmUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
María OlmedoDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Margarita OrejasInstituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Avenida Catedrático Agustín Escardino 7, 46980 Paterna, Valencia, Spain.
Lucila Ortiz-CastellanosDepartamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.
Antonio G PisabarroDepartment of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.
Julio Rodríguez-RomeroDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
José Ruiz-HerreraDepartamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.
Rosa Ruiz-VázquezDepartamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.
Catalina SanzDepartamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
Wendy SchackwitzUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Mahdi ShahriariDepartamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.
Ekaterina ShelestLeibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Beutenbergstrasse 11a, 07745 Jena, Germany.
Fátima Silva-FrancoDepartamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.
Darren SoanesBiosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
Khajamohiddin SyedDepartment of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA.
Víctor G TaguaDepartment of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.
Nicholas J TalbotBiosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
Michael R ThonDepartamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.
Hope TiceUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Ronald P de VriesCBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
Ad WiebengaCBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
Jagjit S YadavDepartment of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA.
Edward L BraunDepartment of Biology, University of Florida, P.O. Box 118525, Gainesville, FL 32611-8525, USA.
Scott E BakerPacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99352, USA.
Victoriano GarreDepartamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.
Jeremy SchmutzUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.
Benjamin A HorwitzDepartment of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel.
Santiago Torres-MartínezDepartamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.
Alexander IdnurmSchool of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA; School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.
Alfredo Herrera-EstrellaLaboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.
Toni GabaldónCentre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.
Igor V GrigorievUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
Joint Genome Institute · USUniversidad de Sevilla · ESUniversidad de Salamanca · ESUniversidad de Murcia · ESDuke University · USUtrecht University · NLInstituto Tecnológico Superior de Irapuato · MXTechnion – Israel Institute of Technology · ILUniversidad Publica de Navarra · ESUniversité de Montréal · CAUniversity of Cincinnati Medical Center · USUniversity of Exeter · GBBattelle · USCentre National de la Recherche Scientifique · FRCIC bioGUNE · ESConsejo Superior de Investigaciones Científicas · ESInstitució Catalana de Recerca i Estudis Avançats · ESInstituto de Recursos Naturales y Agrobiología de Sevilla · ESIshinomaki Senshu University · JPKansas City University · US
Funding
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5MNIAID NIH HHS R01 AI050113
Abstract
Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.
Indexed as
Evolution, MolecularGene DuplicationGenome, FungalLightMucorMultigene FamilyPerceptionPhycomycesSignal TransductionTranscription, Genetic
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