ArticleCell2016
A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction.
Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 155 citations in OpenAlex.
- Diving Into the Chemical World of Cetaceans: A Review on the Chemical Senses in Dolphins and Whales.Journal of chemical ecology · 2026Review
- Ectopic Olfactory Receptors in Oral Health and Disease: Molecular Links Between Chemosensing, Tissue Repair, Inflammation, and Cancer.International journal of molecular sciences · 2026Review
- The challenge of distinguishing living from non-living entities.Theory in biosciences = Theorie in den Biowissenschaften · 2026Review
- A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice.Current biology : CB · 2026Article
- Glomeruli of the Mouse Olfactory Bulb: Numbers, Sizes, Shapes.The European journal of neuroscience · 2025Article
- The Ubiquitin-Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Review
- When noncanonical olfaction is optimal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- Complex genetic interactions affect susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A loci.GeroScience · 2025Article
- Harnessing Odorant Receptor Activation to Suppress Real Malodor.International journal of molecular sciences · 2025Article
- Constancy of olfactory cilia in rodents.Chemical senses · 2025Article
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
- Calcium Imaging in Olfaction: Non-rodent Mammalian Species.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Airway sensory systems: breathing new life into microbiota-brain communication.Frontiers in cellular neuroscience · 2025Review
- Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons.PLoS biology · 2024Article
- Odor representation and coding by the mitral/tufted cells in the olfactory bulb.Journal of Zhejiang University. Science. B · 2024Review
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Establishment and maintenance of random monoallelic expression.Development (Cambridge, England) · 2024Review
- CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators.Nature communications · 2024Article
- Epigenetic programming of stochastic olfactory receptor choice.Genesis (New York, N.Y. : 2000) · 2024Review
19 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Odor perception in mammals is mediated by parallel sensory pathways that convey distinct information about the olfactory world. Multiple olfactory subsystems express characteristic seven-transmembrane G-protein-coupled receptors (GPCRs) in a one-receptor-per-neuron pattern that facilitates odor discrimination. Sensory neurons of the "necklace" subsystem are nestled within the recesses of the olfactory epithelium and detect diverse odorants; however, they do not express known GPCR odor receptors. Here, we report that members of the four-pass transmembrane MS4A protein family are chemosensors expressed within necklace sensory neurons. These receptors localize to sensory endings and confer responses to ethologically relevant ligands, including pheromones and fatty acids, in vitro and in vivo. Individual necklace neurons co-express many MS4A proteins and are activated by multiple MS4A ligands; this pooling of information suggests that the necklace is organized more like subsystems for taste than for smell. The MS4As therefore define a distinct mechanism and functional logic for mammalian olfaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.