ArticleJournal of atherosclerosis and thrombosis2017
Patients with an Inflamed Atherosclerotic Plaque have Increased Levels of Circulating Inflammatory Markers.
Article in Journal of atherosclerosis and thrombosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- IL-6 and Surgical Outcomes in Carotid Endarterectomy: A Systematic Review.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Inflammation-A Link Between Arterial Atherosclerotic and Venous Thromboembolic Diseases.Cells · 2025Review
- Intra-Individual Reproducibility of Early and Late C-Reactive Protein and Interleukin-6 in Patients with Non-Severe Ischaemic Stroke and Carotid Atherosclerosis.Cerebrovascular diseases extra · 2025Observational
- Association of endothelial function and limb artery indices with coronary artery stenosis severity in patients with hypertension.Annals of medicine · 2024Article
- Imaging of atherosclerosis with [Scientific reports · 2023Article
- Revascularization for asymptomatic carotid artery stenosis improves balance and mobility.Journal of vascular surgery · 2021Article
- Efficacy of simvastatin on carotid atherosclerotic plaque and its effects on serum inflammatory factors and cardiocerebrovascular events in elderly patients.Experimental and therapeutic medicine · 2021Article
- New insight into biology, molecular diagnostics and treatment options of unstable carotid atherosclerotic plaque: a narrative review.Annals of translational medicine · 2021Review
- Gait and Balance Disorder in Patients with Transient Ischemic Attack or Minor Stroke.Neuropsychiatric disease and treatment · 2021Article
- Inflammation of carotid plaques and risk of cerebrovascular events.Annals of translational medicine · 2020Review
- Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.The Journal of clinical endocrinology and metabolism · 2020Observational
- Asymptomatic carotid stenosis is associated with mobility and cognitive dysfunction and heightens falls in older adults.Journal of vascular surgery · 2020Article
- Circulating Hematopoietic Stem/Progenitor Cells are Associated with Coronary Stenoses in Patients with Coronary Heart Disease.Scientific reports · 2019Article
- Circulating Sulfatide, A Novel Biomarker for ST-Segment Elevation Myocardial Infarction.Journal of atherosclerosis and thrombosis · 2019Article
- Neopterin as a Marker of In-Stent Restenosis: to Have or Have Not.Journal of atherosclerosis and thrombosis · 2018Article
- Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies.Cardiovascular diabetology · 2018Review
- Noninvasive Coronary Plaque Imaging.Journal of atherosclerosis and thrombosis · 2018Review
- Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study.Journal of atherosclerosis and thrombosis · 2018Article
- Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques.Molecular medicine reports · 2017Article
- Femoral Artery Atherosclerosis Is Associated With Physical Function Across the Spectrum of the Ankle-Brachial Index: The San Diego Population Study.Journal of the American Heart Association · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimInflammation is highlighted in the pathogenesis and destabilization of atherosclerotic lesions. Noninvasive identification of inflammation of atherosclerotic lesions has been challenging. 18-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is a useful technique for detecting inflamed atherosclerotic plaques in vivo. However, it is time consuming, expensive, and accompanied by radiation. Therefore, we investigated the relationship between levels of circulating inflammatory markers and the degree of inflammation of atherosclerotic plaques shown by 18F-FDG uptake. We aimed to identify high-risk patients with inflamed, unstable atherosclerotic plaques on the basis of the determination of inflammatory markers.
methodsThe study included 37 patients, 21 with high-grade stenosis of internal carotid artery (ICA group) and 16 with occlusion of common femoral artery (CFA group), who underwent endarterectomy. Mean age of the study population was 69.43±6.2 years. Eight out of 21 patients with ICA stenosis and all patients with CFA occlusion were symptomatic. In all patients before endarterectomy, 18F-FDG-PET imaging was performed and blood samples were obtained for determination of circulating inflammatory markers: high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), interleukins, and selectins. Both groups were compared with a sex- and age-matched control group composed of 27 healthy volunteers.
results18F-FDG uptake, calculated by target-to-background ratio (TBR) was not significantly different between the groups. Levels of inflammatory markers were elevated, and there were no significant differences between ICA and CFA groups, with an exception of interleukin 6 (IL-6) levels, which was higher in the ICA group (3.2±2.5 ng/L vs. 1.8±1.3 ng/L, p＜0.05). There was a positive interrelationship between 18F-FDG-PET and most of the systemic inflammatory markers: hsCRP (r=0.417, p=0.010), IL-6 (r=0.603, p＜0.001), and TNF-α (r=0.374, p=0.023). However, correlation between 18F-FDG-PET and P-selectin, E-selectin, and t-PA was not found.
conclusionOur study showed that an interrelationship exists between the intensity of inflammatory process of atherosclerotic lesions shown by FDG uptake and circulating inflammatory markers. Therefore, the determination of circulating inflammatory markers can have a potential to identify individuals with unstable, inflamed atherosclerotic plaques.
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