ArticleAmerican journal of human genetics2016
Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children.
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Article in American journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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21citing papers in PubMed, 2 pooled it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Trans-ethnic genome-wide association study of severe COVID-19.Communications biology · 2021Pooled it
- Host genetic variability and pneumococcal disease: a systematic review and meta-analysis.BMC medical genomics · 2019Pooled it
- Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.Science advances · 2017Trial
- African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.Nature communications · 2026Article
- Diagnostic and prognostic value of LINC00278 in patients with severe pneumonia and its regulatory role.Journal of inflammation (London, England) · 2026Article
- Relation Between the Dantu Blood Group Variant and Bacteremia in Kenyan Children: A Population-Based Case-Control Study.The Journal of infectious diseases · 2025Article
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- Transcriptome Profiling Reveals CD73 and Age-Driven Changes in Neutrophil Responses against Streptococcus pneumoniae.Infection and immunity · 2021Article
- These Are the Genes You're Looking For: Finding Host Resistance Genes.Trends in microbiology · 2021Review
- Malaria is a cause of iron deficiency in African children.Nature medicine · 2021Article
- Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency.BMC medicine · 2020Article
- Significance of Single-Nucleotide Variants in Long Intergenic Non-protein Coding RNAs.Frontiers in cell and developmental biology · 2020Review
- Disease-Causing Mutations and Rearrangements in Long Non-coding RNA Gene Loci.Frontiers in genetics · 2020Review
- Commentary: CRP and schizophrenia: cause, consequence or confounding?International journal of epidemiology · 2019Article
- Article
- Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.Nature communications · 2019Article
- Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses.Frontiers in genetics · 2019Article
- Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Review
- Genetic variation inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.Nature communications · 2018Article
Corrections and comments
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Authors and funding
60 authors at 16 institutions in 6 countries.
Kenyan Bacteraemia Study Group
Wellcome Trust Case Control Consortium 2 (WTCCC2)
Anna RautanenWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address: anna.rautanen@well.ox.ac.uk.
Matti PirinenWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Tara C MillsWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Kirk A RockettWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Amy StrangeWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Anne W NdunguWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Vivek NaranbhaiWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
James J GilchristWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; Department of Paediatrics, University of Oxford, Oxford OX3 9DU, UK.
Céline BellenguezWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Colin FreemanWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Gavin BandWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Suzannah J BumpsteadWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Sarah EdkinsWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Eleni GiannoulatouWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Emma GrayWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Serge DronovWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Sarah E HuntWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Cordelia LangfordWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Richard D PearsonWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Zhan SuWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Damjan VukcevicWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Alex W MachariaKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Sophie UyogaKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Carolyne NdilaKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Neema MturiKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Patricia NjugunaKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Shebe MohammedKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
James A BerkleyKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Isaiah MwangiKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Salim MwarumbaKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Barnes S KitsaoKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Brett S LoweKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Susan C MorpethKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya; Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 9DU, UK; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Iqbal KhandwallaKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya.
Kilifi Bacteraemia Surveillance Group
Jenefer M BlackwellCambridge Institute for Medical Research and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK; Telethon Kids Institute, The University of Western Australia, Subiaco, WA 6008, Australia.
Elvira BramonNational Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at the South London and Maudsley National Health Service (NHS) Foundation Trust and Institute of Psychiatry, King's College London, Denmark Hill, London SE5 8AF, UK.
Matthew A BrownInstitute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia.
Juan P CasasFarr Institute of Health Informatics, University College London, London NW1 2DA, UK.
Aiden CorvinNeuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland.
Audrey DuncansonMolecular and Physiological Sciences, The Wellcome Trust, London NW1 2BE, UK.
Janusz JankowskiAssociate Deans Office, John Bull Building, Peninsula School of Medicine and Dentistry, Plymouth PL6 8BU, UK.
Hugh S MarkusDepartment of Neurology, University of Cambridge, Cambridge CB2 0QQ, UK.
Christopher G MathewDivision of Genetics and Molecular Medicine, King's College London, London SE1 9RT, UK; Sydney Brenner Institute for Molecular Bioscience, University of Witwatersrand, Johannesburg 2193, South Africa.
Colin N A PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Robert PlominMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
Stephen J SawcerDepartment of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Richard C TrembathLondon School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Ananth C ViswanathanNIHR Biomedical Research Centre at Moorfields Eye Hospital NHSFT and UCL Institute of Ophthalmology, London EC1V 2PD, UK.
Nicholas W WoodDepartment of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Panos DeloukasWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Leena PeltonenWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Thomas N WilliamsKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya; Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 9DU, UK; Department of Medicine, Imperial College, London W21NY, UK; INDEPTH Network, Accra, Ghana.
J Anthony G ScottKEMRI-Wellcome Trust Research Programme, Kilifi 80108, Kenya; Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 9DU, UK; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Stephen J ChapmanWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford University Hospitals, Oxford OX3 7LE, UK.
Peter DonnellyWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.
Adrian V S HillWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
Chris C A SpencerWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.
Centre for Human Genetics · GBKenya Medical Research Institute · KEWellcome Sanger Institute · GBKing's College London · GBUniversity of Cambridge · GBFarr Institute · GBMoorfields Eye Hospital NHS Foundation Trust · GBNational Health Service · GBNational Hospital for Neurology and Neurosurgery · GBPeninsula College of Medicine and Dentistry · GBQueen Mary University of London · GBThe Kids Research Institute Australia · AUTranslational Research Institute · AUTrinity College Dublin · IEUniversity of Dundee · GBWellcome Trust · GB
Funding
Department of Health PDA/02/06/016European Research Council 294557Medical Research Council G0901310Medical Research Council G1001712Medical Research Council MR/M007367/1Wellcome Trust
Abstract
Bacteremia (bacterial bloodstream infection) is a major cause of illness and death in sub-Saharan Africa but little is known about the role of human genetics in susceptibility. We conducted a genome-wide association study of bacteremia susceptibility in more than 5,000 Kenyan children as part of the Wellcome Trust Case Control Consortium 2 (WTCCC2). Both the blood-culture-proven bacteremia case subjects and healthy infants as controls were recruited from Kilifi, on the east coast of Kenya. Streptococcus pneumoniae is the most common cause of bacteremia in Kilifi and was thus the focus of this study. We identified an association between polymorphisms in a long intergenic non-coding RNA (lincRNA) gene (AC011288.2) and pneumococcal bacteremia and replicated the results in the same population (p combined = 1.69 × 10(-9); OR = 2.47, 95% CI = 1.84-3.31). The susceptibility allele is African specific, derived rather than ancestral, and occurs at low frequency (2.7% in control subjects and 6.4% in case subjects). Our further studies showed AC011288.2 expression only in neutrophils, a cell type that is known to play a major role in pneumococcal clearance. Identification of this novel association will further focus research on the role of lincRNAs in human infectious disease.
Indexed as
AdolescentBacteremiaCase-Control StudiesChildChild, PreschoolGenome-Wide Association StudyHumansInfantInfant, NewbornKenyaPneumonia, PneumococcalPolymorphism, GeneticRisk FactorsRNA, Long NoncodingStreptococcus pneumoniaeRNA, Long Noncoding
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