ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016
Histopathology of the filum terminale in children with and without tethered cord syndrome with attention to the elastic tissue within the filum.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Anatomical and histological characterization of the filum terminale in dogs.Frontiers in veterinary science · 2025Article
- Diagnosis and Management of Tethered Cord Syndrome.Advances and technical standards in neurosurgery · 2024Article
- Classification of and individual treatment strategies for complex tethered cord syndrome.Frontiers in surgery · 2024Article
- [Classification and microsurgical treatment of primary tethered cord syndrome in adults].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- A systematic review and meta-analysis of minimally invasive surgery in children with occult tethered cord syndrome.Translational pediatrics · 2022Article
- Occult tethered cord syndrome: a rare, treatable condition.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Subpial Lumbar Lipoma Associated with Retained Medullary Cord.NMC case report journal · 2021Article
- Review
- Oculo-Auriculo-Vertebral Dysplasia With Craniocervical Instability and Occult Tethered Cord Syndrome. An Addition to the Spectrum? First Case Report and Review of the Literature.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2019Review
- Expression of Sigma-Class Glutathione-S-Transferase in Fetal and Pediatric Filum Terminale Samples: A Comparative Study.Medicina (Kaunas, Lithuania) · 2019Article
- Fatty filum terminale (FFT) as a secondary tethering element in children with closed spinal dysraphism.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Dynamic Lumbosacral Magnetic Resonance Imaging in a Dog with Tethered Cord Syndrome with a Tight Filum Terminale.Frontiers in veterinary science · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare histologically transected fila from pediatric patients with tethered cord syndrome (TCS), with and without a low conus, with controls, focusing on collagenous and elastic tissue.
methodsThirty fila from patients with TCS, including 5 where minimal cautery was used prior to filum section, were compared with fila from 27 pediatric cadavers without TCS (controls). Sections of fila were stained with H&E, Masson trichrome and Verhoeff von Gieson elastic stains, and 7 with Gordon and Sweet's reticulin stain.
resultsFila from controls showed loose fibrous connective tissue (FCT) with thin and evenly dispersed elastic fibers (EFs). Reticulin fibers (RFs) were seen in blood vessel walls and nerve twigs. Fat was identified microscopically in 2 fila. All fila from patients with TCS had dense FCT. The EFs were in normal numbers in 17, and focally or diffusely decreased in 13. All 25 patients where the fila were cauterized during resection had thick and coiled EFs. Coiling was not seen when minimal cautery was applied. RFs were seen in blood vessel walls and nerve twigs. Fat was identified in 19 patients. Findings were similar, whether the conus termination was normal or low.
conclusionThe fila of all patients with TCS, whether or not the conus was low, showed abnormal FCT. EFs were decreased in 48 % of patients; however, there were thick and coiled EFs in all patients. Coiling of EFs, initially thought to be an abnormality in patients, is considered most likely to be a result of cautery (i.e., artifactual/iatrogenic coiling).
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