ArticlePsychoneuroendocrinology2016
The developmental relationship between DHEA and visual attention is mediated by structural plasticity of cortico-amygdalar networks.
Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Adrenarche, social cognition, and the development and evolution of autism spectrum traits.Frontiers in psychiatry · 2025Pooled it
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Examining androgen and estrogen profiles during pubertal development in autistic and neurotypical girls.Hormones and behavior · 2025Article
- Cognitive performance in young adult women with a history of premature adrenarche.Pediatric research · 2025Article
- The Cortico-Limbo-Thalamo-Cortical Circuits: An Update to the Original Papez Circuit of the Human Limbic System.Brain topography · 2023Review
- Prenatal paternal anxiety symptoms predict child DHEA levels and internalizing symptoms during adrenarche.Frontiers in behavioral neuroscience · 2023Article
- Positive or negative environmental modulations on human brain development: the morpho-functional outcomes of music training or stress.Frontiers in neuroscience · 2023Review
- Impacts of adrenarcheal DHEA levels on spontaneous cortical activity during development.Developmental cognitive neuroscience · 2022Article
- Hair cortisol and dehydroepiandrosterone concentrations: Associations with executive function in early childhood.Biological psychology · 2020Article
- Effects of age, sex, and puberty on neural efficiency of cognitive and motor control in adolescents.Brain imaging and behavior · 2020Article
- DHEAS and Human Development: An Evolutionary Perspective.Frontiers in endocrinology · 2020Article
- Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills.Journal of neuroendocrinology · 2019Article
- Sex-specific contribution of DHEA-cortisol ratio to prefrontal-hippocampal structural development, cognitive abilities and personality traits.Journal of neuroendocrinology · 2019Article
- Amygdalar reactivity is associated with prefrontal cortical thickness in a large population-based sample of adolescents.PloS one · 2019Article
- Coalitional Physical Competition : Acute Salivary Steroid Hormone Responses among Juvenile Male Soccer Players in Hong Kong.Human nature (Hawthorne, N.Y.) · 2018Article
- Puberty and the human brain: Insights into adolescent development.Neuroscience and biobehavioral reviews · 2018Review
- Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development.Psychoneuroendocrinology · 2017Article
- Polymorphisms of STS gene and SULT2A1 gene and neurosteroid levels in Han Chinese boys with attention-deficit/hyperactivity disorder: an exploratory investigation.Scientific reports · 2017Article
- Puberty and structural brain development in humans.Frontiers in neuroendocrinology · 2017Review
- Disentangling the unique associations of age, pubertal stage, and pubertal hormones with white matter microstructure in childhood and adolescence.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Humans and the great apes are the only species demonstrated to exhibit adrenarche, a key developmental event leading to increased production of dehydroepiandrosterone (DHEA), suggesting that this hormone may play an important evolutionary role. Similarly, visual attention networks have been shown to evolve in a human-specific manner, with some anatomical connections and elements of cortical organization exclusive to our species. Existing studies of human brain development support the notion that DHEA shows significant uptake in cortical structures and the amygdala, and as such, could be involved in the bottom-up regulation of visual attention. Here we examined associations between DHEA, structural covariance of the amygdala with whole-brain cortical thickness, and tests of visual attention, in a longitudinal sample of typically developing children and adolescents 6-22 years of age. We found that DHEA predicted covariance between amygdalar volume and the left occipital pole, right somatosensory parietal cortex and right anterior cingulate cortex. Amygdala-occipital covariance predicted visual awareness; amygdala-parietal covariance predicted visuo-motor dexterity and processing speed; amygdala-prefrontal covariance predicted global attentional impairment. Further, effects of DHEA were above and beyond those of age and sex, as well as distinct from those of pubertal stage, estradiol and testosterone. These findings support the notion that DHEA may play a unique role in shaping amygdala-dependent cortical plasticity and in regulating 'bottom-up' visual attention processes from childhood to young adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.