Evidence map›Paper›PMID 27236499›Full record

ArticleThe Journal of allergy and clinical immunology2016

Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy.

Xiumei Hong, Christine Ladd-Acosta, Ke Hao, Ben Sherwood, Hongkai Ji, Corinne A Keet, Rajesh Kumar, Deanna Caruso, Xin Liu, Guoying Wang and 11 more

Open access · bronzeAbstract readLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
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  9. Review
  10. Epigenomic and epigenetic investigations of food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Review
  11. Multi-omics profiling approach in food allergy.The World Allergy Organization journal · 2023
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Advancing Food Allergy Through Omics Sciences.The journal of allergy and clinical immunology. In practice · 2021
    Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 3 countries.

Xiumei HongDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Christine Ladd-AcostaDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Ke HaoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Ben SherwoodDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Hongkai JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Corinne A KeetDivision of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md.
Rajesh KumarDivision of Allergy and Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Deanna CarusoDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Xin LiuKey Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Guoying WangDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Zhu ChenDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Yuelong JiDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Guanyun MaoDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md; Department of Preventive Medicine, School of Environmental Science & Public Health, Wenzhou Medical University, Wenzhou, China.
Sheila Ohlsson WalkerDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md; Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University, Tempe, Ariz; The Johns Hopkins School of Education, Baltimore, Md.
Tami R BartellMary Ann & J. Milburn Smith Child Health Research Program, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Zhicheng JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Yifei SunDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Hui-Ju TsaiDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Ill; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Jacqueline A PongracicDivision of Allergy and Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Daniel E WeeksDepartments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa.
Xiaobin WangDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md; Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address: xwang82@jhu.edu.
Johns Hopkins University · USLurie Children's Hospital · USNorthwestern University · USIcahn School of Medicine at Mount Sinai · USUniversity of Pittsburgh · US

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth CohortR01HD086013 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LEE, BRUCE Y, WANG, XIAOBIN · 2016 to 2020
$3.3M
Post Genome-Wide Association Study of Food AllergyU01AI090727 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2014
$2.3M
Genome-Wide Association Study of Food AllergyR56AI080627 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2009 to 2010
$1.3M
Genetic and Environmental Determinants of Food AllergyK23AI103187 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KEET, CORINNE · 2012 to 2016
$684k
Molecular Epidemiology of Preterm BirthR21ES011666 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2002 to 2004
$562k
Prenatal Multi-Level Stressors and Alterations in Maternal and Fetal EpigenomesR21HD085556 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SURKAN, PAMELA J, WANG, XIAOBIN · 2016 to 2017
$449k
Establishing Precursors of Food Allergy in NewbornsR21AI079872 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2008 to 2009
$447k
Epigenome Association Study of Food AllergyR21AI088609 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2011
$409k
Epigenome-wide Association Study of Preterm BirthR21HD066471 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2011
$354k
NIAID NIH HHS K23 AI103187NIAID NIH HHS R21 AI079872NIAID NIH HHS R21 AI088609NIAID NIH HHS R56 AI080627NIAID NIH HHS U01 AI090727NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD086013NICHD NIH HHS R21 HD066471NICHD NIH HHS R21 HD085556NIEHS NIH HHS R21 ES011666
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCattleChild, PreschoolDNA MethylationFemaleGenome-Wide Association StudyHumansImmunoglobulin EMaleMilk HypersensitivityImmunoglobulin E

Identifiers

PMID27236499
PMCPMC5392112
OpenAlexW2343935000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.