ArticleVirology2016
The genome of AR9, a giant transducing Bacillus phage encoding two multisubunit RNA polymerases.
Article in Virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- The biology of jumbo phages.Nature communications · 2026Review
- Characterization ofEngineering microbiology · 2026Article
- Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A novel lineage of large aquatic bacteriophages identified through metagenomics.Archives of virology · 2025Article
- The Biology of Nucleus-Forming Jumbo Phages.Annual review of genetics · 2025Review
- Presence of group II introns in phage genomes.Nucleic acids research · 2025Article
- Novel Giant Phages vB_AerVM_332-Vera and vB_AerVM_332-Igor and Siphophage vB_AerVS_332-Yulya Infecting the SameViruses · 2025Article
- Article
- Characteristics and whole-genome analysis of a novel Pseudomonas syringae pv. tomato bacteriophage D6 isolated from a karst cave.Virus genes · 2024Article
- Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail.Nature communications · 2024Article
- Genomic and proteomic characterization of vB_SauM-UFV_DC4, a novel Staphylococcus jumbo phage.Applied microbiology and biotechnology · 2023Article
- Isolation, Characterization and Genomic Analysis of a Novel Jumbo Phage, AerS_266, That InfectsMicroorganisms · 2023Article
- The Dynamics of Synthesis and Localization of Jumbo Phage RNA Polymerases inside Infected Cells.Viruses · 2023Article
- A Multimodal Approach towards Genomic Identification of Protein Inhibitors of Uracil-DNA Glycosylase.Viruses · 2023Article
- Article
- Characterization and genomic study of EJP2, a novel jumbo phage targeting antimicrobial resistantFrontiers in microbiology · 2023Article
- NovelViruses · 2022Article
- Article
- Interactions between Jumbo Phage SA1 andMicroorganisms · 2022Article
- Viral Complexity.Biomolecules · 2022Review
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Authors and funding
9 authors.
Funding
Abstract
Bacteriophage AR9 and its close relative PBS1 have been extensively used to construct early Bacillus subtilis genetic maps. Here, we present the 251,042bp AR9 genome, a linear, terminally redundant double-stranded DNA containing deoxyuridine instead of thymine. Multiple AR9 genes are interrupted by non-coding sequences or sequences encoding putative endonucleases. We show that these sequences are group I and group II self-splicing introns. Eight AR9 proteins are homologous to fragments of bacterial RNA polymerase (RNAP) subunits β/β'. These proteins comprise two sets of paralogs of RNAP largest subunits, with each paralog encoded by two disjoint phage genes. Thus, AR9 is a phiKZ-related giant phage that relies on two multisubunit viral RNAPs to transcribe its genome independently of host transcription apparatus. Purification of one of PBS1/AR9 RNAPs has been reported previously, which makes AR9 a promising object for further studies of RNAP evolution, assembly and mechanism.
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