Evidence map›Paper›PMID 27235820›Full record

ArticleJournal of affective disorders2016

Late-life depression symptom dimensions and cognitive functioning in the Longitudinal Aging Study Amsterdam (LASA).

Anamaria Brailean, Hannie C Comijs, Marja J Aartsen, Martin Prince, A Matthew Prina, Aartjan Beekman, Martijn Huisman

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In one paragraph

Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anamaria BraileanKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Health Service and Population Research, Centre for Global Mental Health, London, UK. Electronic address: brailean.anamaria@gmail.com.
Hannie C ComijsVU University Medical Centre, Department of Psychiatry and the EMGO Institute for Health and Care Research, Amsterdam, the Netherlands.
Marja J AartsenNOVA - Norwegian Social Research, Center for Welfare and Labor Research, Oslo, Norway.
Martin PrinceKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Health Service and Population Research, Centre for Global Mental Health, London, UK.
A Matthew PrinaKing's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Health Service and Population Research, Centre for Global Mental Health, London, UK.
Aartjan BeekmanVU University Medical Centre, Department of Psychiatry and the EMGO Institute for Health and Care Research, Amsterdam, the Netherlands.
Martijn HuismanVU University, Department of Sociology, Amsterdam, the Netherlands; VU University Medical Center, Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, Department of Sociology, Amsterdam, the Netherlands.

Funding

Medical Research Council MR/K021907/1
6 · The paper itself

Abstract

backgroundDepression often co-occurs in late-life in the context of declining cognitive functions, but it is not clear whether specific depression symptom dimensions are differentially associated with cognitive abilities.

methodsThe study sample comprised 3107 community-dwelling older adults from the Longitudinal Aging Study Amsterdam (LASA). We applied a Multiple Indicators Multiple Causes (MIMIC) model to examine the association between cognitive abilities and latent dimensions of the Center for Epidemiologic Studies Depression Scale (CES-D), while accounting for differential item functioning (DIF) due to age, gender and cognitive function levels.

resultsA factor structure consisting of somatic symptoms, positive affect, depressed affect, and interpersonal difficulties fitted the data well. Higher levels of inductive reasoning were significantly associated with lower levels of depressed affect and somatic symptoms, whereas faster processing speed was significantly associated with lower levels of somatic symptoms. DIF due to age and gender was found, but the magnitude of the effects was small and did not alter substantive conclusions. LIMITATIONS: Due to the cross-sectional context of this investigation, the direction of influence between depression symptom levels and cognitive function levels cannot be established. Furthermore, findings are relevant to non-clinical populations, and they do not clarify whether certain DIF effects may be found only at high or low levels of depression.

conclusionsOur findings suggest differential associations between late-life depression dimensions and cognitive abilities in old age, and point towards potential etiological mechanisms that may underline these associations. These findings carry implications for the prognosis of cognitive outcomes in depressed older adults.

Indexed as

AgedAged, 80 and overAgingCognitionCognition DisordersCross-Sectional StudiesDepressive DisorderFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleNetherlandsCognitive abilitiesCognitive agingDepression symptom dimensionsDifferential item functioningLate-life depression

Identifiers

PMID27235820
PMCPMC4914607

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.