Evidence map›Paper›PMID 27235530›Full record

Trial reportThe bone & joint journal2016

The administration of intermittent parathyroid hormone affects functional recovery from trochanteric fractured neck of femur: a randomised prospective mixed method pilot study.

T J S Chesser, R Fox, K Harding, R Halliday, S Barnfield, K Willett, S Lamb, C Yau, M K Javaid, A C Gray and 4 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The bone & joint journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Effectiveness of parathyroid hormone (PTH) analogues on fracture healing: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Teriparatide and pelvic fracture healing: a phase 2 randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. Timing of osteoporosis therapies following fracture: the current status.Therapeutic advances in endocrinology and metabolism · 2022
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Is calcium phosphate augmentation a viable option for osteoporotic hip fractures?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

T J S ChesserSouthmead Hospital, North Bristol NHS Trust, Bristol, BS10 5NB, UK.
R FoxSouthmead Hospital, North Bristol NHS Trust, Bristol, BS10 5NB, UK.
K HardingSouthmead Hospital, North Bristol NHS Trust, Bristol, BS10 5NB, UK.
R HallidaySouthmead Hospital, North Bristol NHS Trust, Bristol, BS10 5NB, UK.
S BarnfieldSouthmead Hospital, North Bristol NHS Trust, Bristol, BS10 5NB, UK.
K WillettKadoorie Research Centre, John Radcliffe Hospital, Headley Way, Oxford OX9 3DU, UK.
S LambUniversity of Oxford, Windmill Road, Oxford OX3 7LD, UK.
C YauStoke Mandeville Hospital, Aylesbury HP21 8AL, UK.
M K JavaidUniversity of Oxford, Windmill Road, Oxford OX3 7LD, UK.
A C GrayRoyal Victoria Infirmary, Newcastle-upon-Tyne, UK.
J YoungUniversity Hospitals Coventry and Warwick, Coventry, UK.
H TaylorUniversity of Bristol NHS Foundation Trust, Education Centre, Level 3, Maudlin Street, Bristol BS2 8AE, UK.
K ShahKadoorie Research Centre, John Radcliffe Hospital, Headley Way, Oxford OX9 3DU, UK.
R GreenwoodUniversity of Bristol NHS Foundation Trust, Education Centre, Level 3, Maudlin Street, Bristol BS2 8AE, UK.
Royal Victoria Infirmary · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity Hospitals Coventry and Warwickshire NHS Trust · GBUniversity of Bristol · GB

Funding

Department of Health PB-PG-0408-16292
6 · The paper itself

Abstract

aimsWe wished to assess the feasibility of a future randomised controlled trial of parathyroid hormone (PTH) supplements to aid healing of trochanteric fractures of the hip, by an open label prospective feasibility and pilot study with a nested qualitative sub study. This aimed to inform the design of a future powered study comparing the functional recovery after trochanteric hip fracture in patients undergoing standard care, versus those who undergo administration of subcutaneous injection of PTH for six weeks. PATIENTS AND

methodsWe undertook a pilot study comparing the functional recovery after trochanteric hip fracture in patients 60 years or older, admitted with a trochanteric hip fracture, and potentially eligible to be randomised to either standard care or the administration of subcutaneous PTH for six weeks. Our desired outcomes were functional testing and measures to assess the feasibility and acceptability of the study.

resultsA total of 724 patients were screened, of whom 143 (20%) were eligible for recruitment. Of these, 123 were approached and 29 (4%) elected to take part. However, seven patients did not complete the study. Compliance with the injections was 11 out of 15 (73%) showing the intervention to be acceptable and feasible in this patient population. TAKE HOME MESSAGE: Only 4% of patients who met the inclusion criteria were both eligible and willing to consent to a study involving injections of PTH, so delivering this study on a large scale would carry challenges in recruitment and retention. Methodological and sample size planning would have to take this into account. PTH administration to patients to enhance fracture healing should still be considered experimental. Cite this article: Bone Joint J 2016;98-B:840-5.

Indexed as

Fracture HealingAgedAged, 80 and overBone Density Conservation AgentsFemaleFemoral Neck FracturesFracture Fixation, InternalHumansInjections, SubcutaneousMaleMedication AdherenceOsteoporotic FracturesPilot ProjectsProspective StudiesSelf AdministrationTeriparatideBone Density Conservation AgentsTeriparatideParathyroid hormoneTrochanteric hip fracture

Identifiers

PMID27235530
PMCPMC4911544
OpenAlexW2395744514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.