ArticleVeterinary research2016
In vivo therapeutic efficacy and pharmacokinetics of colistin sulfate in an experimental model of enterotoxigenic Escherichia coli infection in weaned pigs.
Article in Veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Effect of single parenteral administration of marbofloxacin on bacterial load and selection of resistant Enterobacteriaceae in the fecal microbiota of healthy pigs.BMC veterinary research · 2024Article
- Susceptibility ofAntibiotics (Basel, Switzerland) · 2023Article
- In Vitro Effect on Piglet Gut Microbiota and In Vivo Assessment of Newly Isolated Bacteriophages against F18 EnterotoxigenicViruses · 2023Article
- Summary of methodology used in enterotoxigenicTranslational animal science · 2023Review
- Current Insights Regarding the Role of Farm Animals in the Spread of Antimicrobial Resistance from a One Health Perspective.Veterinary sciences · 2022Review
- Effect of amino acid blend as alternative to antibiotics for growing pigs.Journal of animal science · 2022Article
- The Pheno- and Genotypic Characterization of PorcineMicroorganisms · 2021Article
- Evolution of Pig Fecal Microbiota Composition and Diversity in Response to EnterotoxigenicMicroorganisms · 2021Article
- First detection of mobilized colistin resistanceNew microbes and new infections · 2021Article
- The Use of Colistin in Food-Producing Animals in Estonia-Vaccination as an Effective Alternative to Consumption of Critically Important Antimicrobials in Pigs.Antibiotics (Basel, Switzerland) · 2021Article
- The Effect of Colistin Treatment on the Selection of Colistin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Effects of the antimicrobial peptide WK3 on diarrhea, growth performance and intestinal health of weaned piglets challenged with enterotoxigenicFood & nutrition research · 2021Article
- Pathogen Challenge and Dietary Shift Alter Microbiota Composition and Activity in a Mucin-AssociatedFrontiers in microbiology · 2021Article
- Understanding of Colistin Usage in Food Animals and Available Detection Techniques: A Review.Animals : an open access journal from MDPI · 2020Review
- Article
- Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets.International journal of molecular sciences · 2019Article
- Development of a pig infection model with colistin-resistant Escherichia coli.Veterinary microbiology · 2018Article
- Screening for fecal presence of colistin-resistant Escherichia coli and mcr-1 and mcr-2 genes in camel-calves in southern Tunisia.Acta veterinaria Scandinavica · 2018Article
- Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies.Acta veterinaria Scandinavica · 2017Review
- The fecal presence of enterotoxin and F4 genes as an indicator of efficacy of treatment with colistin sulfate in pigs.BMC microbiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterotoxigenic Escherichia coli (ETEC: F4) associated with post-weaning diarrhea (PWD) in pigs has developed resistance against several antimicrobial families, leading to increased use of colistin sulfate (CS) for the treatment of this disease. The objective of this study was to determine the efficacy of oral CS treatment in experimental PWD due to ETEC: F4 challenge and determine the effect of this challenge on CS intestinal absorption. In this study, 96 pigs were divided into two trials based on CS dose (100 000 or 50 000 IU/kg). Fecal shedding of ETEC: F4, total E. coli, and CS-resistant E. coli, diarrhea scores, and weight changes were evaluated. Colistin sulfate plasma concentrations were determined by HPLC-MS/MS. Regardless of the dose, CS treatment resulted in a reduction of fecal ETEC: F4 and total E. coli shedding, and in diarrhea scores but only during the treatment period. However, CS treatment resulted in a slight increase in fecal shedding of CS resistant E. coli and did not prevent weight loss in challenged pigs. In addition, challenge with ETEC: F4 resulted in an increase of CS intestinal absorption. Our study is among the first to demonstrate that under controlled conditions, CS was effective in reducing fecal shedding of ETEC: F4 and total E. coli in experimental PWD. However, CS treatment was associated with a slight selection pressure on E. coli and did not prevent pig weight loss. Further studies are needed in field conditions, to better characterize CS therapeutic regimen efficacy and bacterial resistance dissemination.
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