ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2016
The role of oral hygiene in head and neck cancer: results from International Head and Neck Cancer Epidemiology (INHANCE) consortium.
Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Investigating the Association Between Oral Hygiene and Oral Cancer: A Systematic Review and Meta-Analysis.Oral diseases · 2026Pooled it
- The accuracy of Fiber-Optic Raman Spectroscopy in the detection and diagnosis of head and neck neoplasmPeerJ · 2023Pooled it
- Evidence of past dental visits and incidence of head and neck cancers: a systematic review and meta-analysis.Systematic reviews · 2019Pooled it
- Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus chemoradiotherapy in head and neck cancer.Nature cancer · 2026Trial
- Article
- Oral Health-Head and Neck Cancers: Addressing Confounding Through Negative Control and Quantitative Bias Analyses.Community dentistry and oral epidemiology · 2026Article
- Periodontitis and Oral and Oropharyngeal Cancer Risk: A Systematic Review and Meta-Analysis with Exploratory Evidence on Tumor-AssociatedDentistry journal · 2026Review
- Oral health and its expanding role in systemic disease, cancer outcomes, and public health.The Lancet regional health. Southeast Asia · 2025Article
- Lip, Oral Cavity, and Pharyngeal Cancers: Global Epidemiology, Risk Factors, and Prevention: A Narrative Review.Health science reports · 2025Article
- Role ofCancer pathogenesis and therapy · 2025Review
- Oral health and the risk of head and neck squamous cell carcinoma: a multicenter case-control study in Iran.Scientific reports · 2025Article
- The European Prospective Investigation into Cancer and Nutrition Cohort (EPIC): a gateway to rare cancer epidemiological research.ESMO rare cancers · 2025Article
- Oral Leukoplakia Microbiome Predicts the Degree of Dysplasia and is Shaped by Smoking and Tooth Loss.Oral diseases · 2025Article
- The complexity of tobacco smoke-induced mutagenesis in head and neck cancer.Nature genetics · 2025Article
- The citizen perspective on challenges and rehabilitation needs among individuals treated for head and neck cancer: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Alveolar bone loss is associated with oral cancer: a case-control study.Frontiers in oral health · 2025Article
- Exploring Factors Influencing Patient Delay Behavior in Oral Cancer: The Development of a Risk Prediction Model in Western China.Healthcare (Basel, Switzerland) · 2024Article
- Periodontitis and risk of cancer: Mechanistic evidence.Periodontology 2000 · 2024Review
- Biological biomarkers of oral cancer.Periodontology 2000 · 2024Review
- Alcohol-Containing Mouthwash and the Risk of Oral Cancer: Exploring the Association.Indian journal of surgical oncology · 2024Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 18 institutions in 10 countries.
Funding
Abstract
backgroundPoor oral hygiene has been proposed to contribute to head and neck cancer (HNC) risk, although causality and independency of some indicators are uncertain. This study investigates the relationship of five oral hygiene indicators with incident HNCs.
methodsIn a pooled analysis of 8925 HNC cases and 12 527 controls from 13 studies participating in the International Head and Neck Cancer Epidemiology Consortium, comparable data on good oral hygiene indicators were harmonized. These included: no denture wear, no gum disease (or bleeding), <5 missing teeth, tooth brushing at least daily, and visiting a dentist ≥once a year. Logistic regression was used to estimate the effects of each oral hygiene indicator and cumulative score on HNC risk, adjusting for tobacco smoking and alcohol consumption.
resultsInverse associations with any HNC, in the hypothesized direction, were observed for <5 missing teeth [odds ratio (OR) = 0.78; 95% confidence interval (CI) 0.74, 0.82], annual dentist visit (OR = 0.82; 95% CI 0.78, 0.87), daily tooth brushing (OR = 0.83, 95% CI 0.79, 0.88), and no gum disease (OR = 0.94; 95% CI 0.89, 0.99), and no association was observed for wearing dentures. These associations were relatively consistent across specific cancer sites, especially for tooth brushing and dentist visits. The population attributable fraction for ≤ 2 out of 5 good oral hygiene indicators was 8.9% (95% CI 3.3%, 14%) for oral cavity cancer.
conclusionGood oral hygiene, as characterized by few missing teeth, annual dentist visits, and daily tooth brushing, may modestly reduce the risk of HNC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.