Evidence map›Paper›PMID 27234445›Full record

ArticleMolecular imaging and biology2016

Synthesis and In Vivo Imaging of N-(3-[

Debora Petroni, Antonietta Bartoli, Simona Rapposelli, Maria Digiacomo, Silvia Burchielli, Giulia Nesi, Annalina Lapucci, Silvia Pardini, Sabrina Fucci, Marco Macchia and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Debora PetroniInstitute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Via Moruzzi, 1, I-56124, Pisa, Italy. debora.petroni@ifc.cnr.it.
Antonietta BartoliMolecular Imaging Centre, University of Turin, Via Nizza, 52, I-10125, Ivrea, Italy.
Simona RapposelliDepartment of Pharmacy, University of Pisa, Via Bonanno 6, I-56126, Pisa, Italy. simona.rapposelli@farm.unipi.it.
Maria DigiacomoDepartment of Pharmacy, University of Pisa, Via Bonanno 6, I-56126, Pisa, Italy.
Silvia BurchielliFondazione Toscana G. Monasterio, Via Moruzzi, 1, I-56124, Pisa, Italy.
Giulia NesiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, I-56126, Pisa, Italy.
Annalina LapucciDepartment of Pharmacy, University of Pisa, Via Bonanno 6, I-56126, Pisa, Italy.
Silvia PardiniInstitute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Via Moruzzi, 1, I-56124, Pisa, Italy.
Sabrina FucciFondazione Toscana G. Monasterio, Via Moruzzi, 1, I-56124, Pisa, Italy.
Marco MacchiaDepartment of Pharmacy, University of Pisa, Via Bonanno 6, I-56126, Pisa, Italy.
Piero A SalvadoriInstitute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Via Moruzzi, 1, I-56124, Pisa, Italy.
Luca MenichettiInstitute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Via Moruzzi, 1, I-56124, Pisa, Italy.
University of Pisa · ITNational Research Council · ITFondazione Toscana Gabriele Monasterio · ITIstituto di Fisiologia Clinica · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe plasma membrane P-glycoprotein (Pgp) is an efflux transporter involved in multidrug resistance and in the onset of neurodegenerative disease. Its function and most mechanisms of action are still under investigation. We developed a C-11-labeled 2-arylethylphenylamine-([ PROCEDURES: The synthetic procedure and the quality control of the selected lead compound, [

resultsIn vivo dynamic imaging was consistent with the results of ex vivo extraction on explanted organs. An adequate stability for in vivo studies, as well as a high activity of [

conclusionsThe suitable pharmacokinetics and the specificity tested in the pre-treated animals have indicated the potentiality of this AEPH derivative to act as Pgp ligand, providing new opportunities for further studies on expression and function of this important efflux transporter in the fields of neurology and oncology.

Indexed as

Aniline CompoundsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1HumansMalePositron-Emission TomographyRats, WistarTissue DistributionAniline CompoundsATP Binding Cassette Transporter, Subfamily B, Member 1N-(3-methoxybenzyl)-2-(3-methoxyphenyl)ethylaniline[11C]-MethylationArylethylphenoxy derivativesArylethylphenylamine derivativesCNS radiotracersMultidrug resistanceP-glycoproteinPgp inhibitorTariquidar

Identifiers

PMID27234445
OpenAlexW2406289207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.