ArticleTranslational respiratory medicine2013
Inhaled corticosteroid influence toll like receptor 2 expression in induced sputum from patients with COPD.
Article in Translational respiratory medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe link between long-term ICS therapy and respiratory infection in COPD patients is controversial. We investigated the effect of long-term use of inhaled corticosteroid on Toll like receptor 2 (TLR2) expression in induced sputum from COPD patients.
methods51 patients were divided into two groups according to their treatment history: long-term ICS treatment group (patients who have used ICS (equivalent to Fluticasone Propionate (FP) ≥ 500 ug/day for more than 1 year) (n = 21) and ICS naive group (who have never routinely used ICS before, n = 29). In their induced sputum, we tested TLR2 extracellular and intracellular expression on macrophages using flowcytometry. TLR2 and tumor necrosis factor αmRNA expression were also evaluated by real-time PCR.
resultsTLR2 extracellular expression on the macrophages from induced sputum in long-term ICS treatment group was lower than the ICS naïve group (13.69% ± 1.17% vs 20.12% ± 4.37%, p = 0.019). TLR2 intracellular expression in the macrophages, the TLR2 and TNFαmRNA in the induced sputum also showed a trend towards decreased endpoint in ICS long-term treatment group compare to ICS naïve group but did not reach significance. TLR2 extracellular and TLR2 intracellular expression were strongly related (r = 0.645, p = P = 0.017) as well as TNFαmRNA and TLR2 mRNA expression (r = 0.894, p = 0.0001).
conclusionLong-term use of ICS may have negative influence on TLR2 expression in the airway of severe COPD patient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.