Evidence map›Paper›PMID 27234211›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2016

CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease.

Min Shi, Andrej Kovac, Ane Korff, Travis J Cook, Carmen Ginghina, Kristin M Bullock, Li Yang, Tessandra Stewart, Danfeng Zheng, Patrick Aro and 10 more

Registry-linked trialOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01720810 (Pacific Northwest Udall Center), which is not on this map. Cited by 128 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 7 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01720810 unknown statusnot on this map

Pacific Northwest Udall Center (PANUC) Clinical Core

TypeobservationalSponsorUniversity of WashingtonRan2010 to 2025Enrolled2,000ConditionsParkinson Disease, Cognitive Impairment
3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 7 syntheses or guidelines pooled it, 210 citations in OpenAlex.

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  14. Extracellular Vesicles in Tauopathies: Mechanisms and Applications.International journal of molecular sciences · 2026
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

Min ShiDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Andrej KovacGeriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Ane KorffDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Travis J CookDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Carmen GinghinaDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Kristin M BullockGeriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Li YangDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Tessandra StewartDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Danfeng ZhengDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Pathology, Peking University Health Science Center and Peking University Third Hospital, Beijing, China.
Patrick AroDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Anzari AtikDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Kathleen F KerrDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Cyrus P ZabetianGeriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Parkinson's Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
Elaine R PeskindDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA; Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
Shu-Ching HuGeriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Parkinson's Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.
Joseph F QuinnDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Douglas R GalaskoDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California at San Diego, La Jolla, CA, USA.
Thomas J MontineDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
William A BanksGeriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Jing ZhangDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Pathology, Peking University Health Science Center and Peking University Third Hospital, Beijing, China. Electronic address: zhangj@uw.edu.
University of Washington · USUniversity of Puget Sound · USGeriatric Research Education and Clinical Center · USInstitute of Neuroimmunology of the Slovak Academy of Sciences · SKOregon Health & Science University · USPeking University Third Hospital · CNUniversity of California, San Diego · US

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BOISE, LINDA · 1990 to 2019
$27.7M
Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
Large Scale Biomarker Discovery and Validation for Parkinsons DiseaseU01NS082137 · NINDS · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2012 to 2016
$6.0M
Biomarkers for Preclinical Parkinson's diseaseR01NS057567 · NINDS · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2008 to 2012
$3.1M
Peptide Biomarkers for Parkinson DiseaseU01NS091272 · NINDS · UNIVERSITY OF WASHINGTON · PI SHI, MIN · 2016 to 2020
$2.1M
Using Multiplex Families to map Genes that Modify Susceptibility and Age at OnsetR01NS065070 · NINDS · UNIVERSITY OF WASHINGTON · PI ZABETIAN, CYRUS P · 2009 to 2012
$2.0M
Interaction of alpha-synuclein and neurotoxicants with Mac1-NADPH oxidaseR01ES019277 · NIEHS · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2011 to 2015
$2.0M
Microglial Phox Activity In Parkinson's DiseaseR01ES016873 · NIEHS · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2010 to 2014
$1.7M
Post-translational Modifications of Proteins in Parkinson?s diseaseR01AG033398 · NIA · UNIVERSITY OF WASHINGTON · PI ZHANG, JING · 2008 to 2012
$1.6M
BLRD VA I01 BX000531NIA NIH HHS P30 AG008017NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG033398NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES016873NIEHS NIH HHS R01 ES019277NINDS NIH HHS P50 NS062684NINDS NIH HHS R01 NS057567NINDS NIH HHS R01 NS065070NINDS NIH HHS R21 NS085425NINDS NIH HHS U01 NS082137NINDS NIH HHS U01 NS091272
6 · The paper itself

Abstract

introductionAlzheimer's disease (AD) and Parkinson's disease (PD) involve tau pathology. Tau is detectable in blood, but its clearance from neuronal cells and the brain is poorly understood.

methodsTau efflux from the brain to the blood was evaluated by administering radioactively labeled and unlabeled tau intracerebroventricularly in wild-type and tau knock-out mice, respectively. Central nervous system (CNS)-derived tau in L1CAM-containing exosomes was further characterized extensively in human plasma, including by single molecule array technology with 303 subjects.

resultsThe efflux of Tau, including a fraction via CNS-derived L1CAM exosomes, was observed in mice. In human plasma, tau was explicitly identified within L1CAM exosomes. In contrast to AD patients, L1CAM exosomal tau was significantly higher in PD patients than controls and correlated with cerebrospinal fluid tau.

conclusionsTau is readily transported from the brain to the blood. The mechanisms of CNS tau efflux are likely different between AD and PD.

Indexed as

AdultAgedAged, 80 and overAlzheimer DiseaseAnimalsBiological TransportBlood-Brain BarrierExosomesFemaleHumansMaleMice, Inbred C57BLMice, KnockoutMiddle AgedNeural Cell Adhesion Molecule L1Parkinson DiseaseMAPT protein, humanMapt protein, mouseNeural Cell Adhesion Molecule L1tau ProteinsAlzheimer's diseaseBiomarkersBlood plasmaCentral nervous system-derived exosomesCentral nervous system protein effluxParkinson's diseaseTau

Identifiers

PMID27234211
PMCPMC5107127
OpenAlexW2398356848

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.