Evidence map›Paper›PMID 27233670›Full record

ArticleG3 (Bethesda, Md.)2016

A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.

Rebecca E McIntyre, Jérôme Nicod, Carla Daniela Robles-Espinoza, John Maciejowski, Na Cai, Jennifer Hill, Ruth Verstraten, Vivek Iyer, Alistair G Rust, Gabriel Balmus and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Rebecca E McIntyreExperimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Jérôme NicodWellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK.
Carla Daniela Robles-EspinozaExperimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla 3001, Santiago de Querétaro 76230, Mexico.
John MaciejowskiLaboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065.
Na CaiWellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK.
Jennifer HillMicrobial Pathogenesis, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Ruth VerstratenExperimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Vivek IyerExperimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
Alistair G RustExperimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK Tumour Profiling Unit, The Institute of Cancer Research, London SW3 6JB, UK.
Gabriel BalmusExperimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, CB2 1QN, UK.
Richard MottWellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK UCL Genetics Institute, University College London, WC1E 6BT, UK.
Jonathan FlintWellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK.
David J AdamsExperimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK da1@sanger.ac.uk.
Wellcome Sanger Institute · GBCentre for Human Genetics · GBRockefeller University · USUniversity College London · GB

Funding

Cancer Research UK 12401Cancer Research UK 18796Wellcome Trust
6 · The paper itself

Abstract

In mammals the regulation of genomic instability plays a key role in tumor suppression and also controls genome plasticity, which is important for recombination during the processes of immunity and meiosis. Most studies to identify regulators of genomic instability have been performed in cells in culture or in systems that report on gross rearrangements of the genome, yet subtle differences in the level of genomic instability can contribute to whole organism phenotypes such as tumor predisposition. Here we performed a genome-wide association study in a population of 1379 outbred Crl:CFW(SW)-US_P08 mice to dissect the genetic landscape of micronucleus formation, a biomarker of chromosomal breaks, whole chromosome loss, and extranuclear DNA. Variation in micronucleus levels is a complex trait with a genome-wide heritability of 53.1%. We identify seven loci influencing micronucleus formation (false discovery rate <5%), and define candidate genes at each locus. Intriguingly at several loci we find evidence for sexual dimorphism in micronucleus formation, with a locus on chromosome 11 being specific to males.

Indexed as

Chromosome BreakageGenome-Wide Association StudyMicronuclei, Chromosome-DefectiveAnimalsChromosome MappingFemaleGenomic InstabilityGenotypeMaleMicePhenotypePolymorphism, Single NucleotideQuantitative Trait LociSex Characteristicsgenetic mappinggenome-wide association study (GWAS)genomic instabilityMicronucleiOutbred mice

Identifiers

PMID27233670
PMCPMC4978889
OpenAlexW2401580443

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.