ArticleNeuroscience2016
Comparable reduction in Zif268 levels and cytochrome oxidase activity in the retrosplenial cortex following mammillothalamic tract lesions.
Article in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Construction of complex memories via parallel distributed cortical-subcortical iterative integration.Trends in neurosciences · 2022Review
- Retrosplenial cortex in spatial memory: focus on immediate early genes mapping.Molecular brain · 2021Review
- Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021Review
- Anterior thalamic nuclei neurons sustain memory.Current research in neurobiology · 2021Article
- Mammillothalamic Disconnection Alters Hippocampocortical Oscillatory Activity and Microstructure: Implications for Diencephalic Amnesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Cognitive Thalamus as a Gateway to Mental Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Lesions within the head direction system reduce retrosplenial c-fos expression but do not impair performance on a radial-arm maze task.Behavioural brain research · 2018Article
- Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat.Brain and neuroscience advancesArticle
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Damage to the mammillothalamic tract (MTT) produces memory impairments in both humans and rats, yet it is still not clear why this diencephalic pathway is vital for memory. One suggestion is that it is an important route for midbrain inputs to reach a wider cortical and subcortical network that supports memory. Consistent with this idea, MTT lesions produce widespread hypoactivity in distal brain regions as measured by the immediate-early gene, c-fos. To determine whether these findings were selective to c-fos or reflected more general changes in neuronal function, we assessed the effects of MTT lesions on the expression of the immediate-early gene protein, Zif268 and the metabolic marker, cytochrome oxidase, in the retrosplenial cortex and hippocampus. The lesions decreased levels of both activity markers in the superficial and deep layers of the retrosplenial cortex in both its granular and dysgranular subregions. In contrast, no significant changes were observed in the hippocampus, despite the MTT-lesioned animals showing marked impairments on T-maze alternation. These findings are consistent with MTT lesions providing important, indirect inputs for normal retrosplenial cortex functioning. These distal functional changes may contribute to the memory impairments observed after MTT lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.