Evidence map›Paper›PMID 27233501›Full record

ReviewCellular and molecular life sciences : CMLS2016

Mitochondrial cAMP signaling.

Fan Zhang, Liping Zhang, Yun Qi, Hong Xu

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 113 citations in OpenAlex.

  1. Trial
  2. Article
  3. Regulation of Translation by PKA Signaling Pathway.International journal of molecular sciences · 2026
    Review
  4. Association of FunctionalInternational journal of molecular sciences · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. The βBritish journal of pharmacology · 2026
    Article
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  10. Review
  11. Article
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  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fan ZhangNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Liping ZhangNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892, USA.
Yun QiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Hong XuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA. xuh5@nhlbi.nih.gov.
National Heart Lung and Blood Institute · USNational Institutes of Health · US

Funding

Mitochondrial DNA inheritance in DrosophilaZIAHL006153 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI XU, HONG · 2012 to 2025
$26.5M
Intramural NIH HHS ZIA HL006153
6 · The paper itself

Abstract

Cyclic adenosine 3, 5'-monophosphate (cAMP) is a ubiquitous second messenger regulating many biological processes, such as cell migration, differentiation, proliferation and apoptosis. cAMP signaling functions not only on the plasma membrane, but also in the nucleus and in organelles such as mitochondria. Mitochondrial cAMP signaling is an indispensable part of the cytoplasm-mitochondrion crosstalk that maintains mitochondrial homeostasis, regulates mitochondrial dynamics, and modulates cellular stress responses and other signaling pathways. Recently, the compartmentalization of mitochondrial cAMP signaling has attracted great attentions. This new input should be carefully taken into account when we interpret the findings of mitochondrial cAMP signaling. In this review, we summarize previous and recent progress in our understanding of mitochondrial cAMP signaling, including the components of the signaling cascade, and the function and regulation of this signaling pathway in different mitochondrial compartments.

Indexed as

Signal TransductionAnimalsCell CompartmentationCyclic AMPHumansMitochondriaModels, BiologicalCyclic AMPAKAPBH3Drp1FissionmtDNAPKAProtein importTFAM

Identifiers

PMID27233501
PMCPMC5097110
OpenAlexW2404856950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.