Trial reportBipolar disorders2016
Acute risk factors for suicide attempts and death: prospective findings from the STEP-BD study.
Trial report in Bipolar disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Anhedonia as a clinical correlate of suicidal thoughts in clinical ketamine trials.Journal of affective disorders · 2017Trial
- Suicide attempt history is associated with blunted neural reward responsiveness after accounting for a history of suicidal ideation and preparatory behaviors.Cognitive, affective & behavioral neuroscience · 2026Article
- Anhedonia nonresponse to short-term ketamine administration for treatment-resistant bipolar depression.Therapeutic advances in psychopharmacology · 2026Article
- Anhedonia and depressive symptoms in adolescent university students from china: the mediating role of early perceive stress.BMC public health · 2025Article
- Prevalence and related factors of first-time suicide attempts in the past 14 days in Chinese adult patients with first-episode drug-naïve major depressive disorder.Frontiers in psychiatry · 2024Article
- Bridge symptoms between parenting styles and proximal psychological risk factors associated with adolescent suicidal thoughts: a network analysis.Child and adolescent psychiatry and mental health · 2023Article
- The association between variability, intensity, and persistence of suicidal ideation and prospective suicidal behavior in the systematic treatment enhancement program for bipolar disorder (STEP-BD) study.International journal of bipolar disorders · 2022Article
- Suicidal Ideation in Bipolar Disorder: The Relation with Clinical and Sociodemographic Variables.The Psychiatric quarterly · 2022Article
- Anhedonia and Suicide.Current topics in behavioral neurosciences · 2022Review
- Inpatient suicide in psychiatric settings: Evaluation of current prevention measures.Frontiers in psychiatry · 2022Review
- Search for solutions, learning, simulation, and choice processes in suicidal behavior.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Network analysis of anxiety and depressive symptoms among quarantined individuals: cross-sectional study.BJPsych open · 2021Article
- Reward Responsiveness in Suicide Attempters: An Electroencephalography/Event-Related Potential Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Symptom trajectories in the months before and after a suicide attempt in individuals with bipolar disorder: A STEP-BD study.Bipolar disorders · 2020Article
- Suicide Risk Assessment and Prevention: Challenges and Opportunities.Focus (American Psychiatric Publishing) · 2020Review
- Anhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes.CNS neuroscience & therapeutics · 2019Review
- Can Anhedonia Be Considered a Suicide Risk Factor? A Review of the Literature.Medicina (Kaunas, Lithuania) · 2019Review
- Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders.Journal of affective disorders · 2019Article
- Modes of Resting Functional Brain Organization Differentiate Suicidal Thoughts and Actions: A Preliminary Study.The Journal of clinical psychiatry · 2018Article
- Relationships between anhedonia, suicidal ideation and suicide attempts in a large sample of physicians.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesSuicide is unfortunately common in psychiatric practice, but difficult to predict. The present study sought to assess which clinical symptoms increase in the months before suicidal behavior in a sample of psychiatric outpatients with bipolar disorder.
methodsData from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) trial were used. A total of 103 participants who attempted suicide or died by suicide during the trial were included; a 15% random sample of the remaining participants (n = 427) was used as a comparison sample. Linear mixed models in the six months before suicidal behavior were conducted for each of five proposed acute risk factors for suicidal behavior. Participants were assessed using the Clinical Monitoring Form (CMF) at each visit for the following potential acute risk factors for suicidal behavior: suicidal ideation, loss of interest, anxiety, psychomotor agitation, and high-risk behavior.
resultsEach of the five symptoms was elevated overall in individuals who engaged in suicidal behavior (p < 0.05). The severity of both suicidal ideation and loss of interest significantly increased in the months before suicidal behavior (p < 0.001). Anxiety demonstrated comparable effect sizes across multiple models. Psychomotor agitation and high-risk behavior were not significantly elevated before suicidal behavior.
conclusionsSuicidal ideation, loss of interest and, to a lesser extent, anxiety may represent acute suicide risk factors up to four months before suicidal behavior in outpatients with bipolar disorder. Further investigation of these potential acute risk factors in prospective analyses is warranted.
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