Evidence map›Paper›PMID 27233218›Full record

ArticleNeuroscience letters2016

Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease.

Joseph C Gully, Valeriy G Sergeyev, Yogesh Bhootada, Hector Mendez-Gomez, Craig A Meyers, Sergey Zolotukhin, Marina S Gorbatyuk, Oleg S Gorbatyuk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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  12. Melatonin Attenuates HInternational journal of molecular sciences · 2022
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  18. ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.Proceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Joseph C GullyDepartment of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Valeriy G SergeyevDepartment of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Biology, Udmurt State University, Izhevsk, Russia.
Yogesh BhootadaDepartment of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Hector Mendez-GomezDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA.
Craig A MeyersDepartment of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Sergey ZolotukhinDepartment of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
Marina S GorbatyukDepartment of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Oleg S GorbatyukDepartment of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Neurology, Center for Neurodegeneration and Experimental Therapy, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: oleggor@uab.edu.
University of Alabama at Birmingham · USUniversity of Florida · US

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAWRENCE C SINCICH · 1985 to 2026
$16.9M
Unfolded Protein Response as a Therapeutic Target for ADRP Animal ModelsR01EY020905 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI GORBATYUK, MARINA · 2010 to 2014
$1.3M
NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY020905
6 · The paper itself

Abstract

Activating transcription factor 4 (ATF4) is a member of the PERK signaling pathway, which directly binds endoplasmic reticulum stress target genes and plays a crucial role in both adaptations to stress and activation of apoptosis. Previous publications demonstrated conflicting evidence on the role of ATF4 in the pathogenesis of neurodegenerative disorders. In this study, we used recombinant adeno-associate virus (rAAV)-mediated gene transfer to investigate if the sustained up-regulation of ATF4 launches a pro-survival or pro-death trend in the dopamine (DA) cells of the substantia nigra pars compacta in a rat model of Parkinson-like neurodegeneration induced by human alpha-synuclein (αS) overexpression. We showed that ATF4 does not protect nigral DA neurons against an αS-induced pathology. Moreover, the rAAV-mediated overexpression of ATF4 resulted in severe nigra-striatal degeneration via activation of caspases 3/7.

Indexed as

ApoptosisActivating Transcription Factor 4alpha-SynucleinAnimalsCaspase 3Caspase 7Disease Models, AnimalDopaminergic NeuronsFemaleHumansParkinson DiseasePars CompactaRatsRats, Sprague-DawleyTyrosine 3-MonooxygenaseUp-RegulationActivating Transcription Factor 4alpha-SynucleinAtf4 protein, ratCasp3 protein, ratCaspase 3Caspase 7Tyrosine 3-MonooxygenaseAAVAlpha-synucleinATF4ER stress responseParkinson's disease

Identifiers

PMID27233218
PMCPMC6052763
OpenAlexW2395966264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.