ArticleThe Plant journal : for cell and molecular biology2016
Nucleotide polymorphism affecting FLC expression underpins heading date variation in horticultural brassicas.
Article in The Plant journal : for cell and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 74 citations in OpenAlex.
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- BolAG-BolRPI2-BolBAM4 Module Regulates the Bolting of Curd by Modulating Starch Metabolism in Broccoli (Brassica oleracea var. italica).Plant biotechnology journal · 2026Article
- All roads lead to Rome: QTL analysis for vernalization requirement and dissection of allelic variation uncovered unexpected diversity ofFrontiers in plant science · 2025Article
- A transcriptomic time-series reveals differing trajectories during pre-floral development in the apex and leaf in winter and spring varieties of Brassica napus.Scientific reports · 2024Article
- Transcriptome profiling reveals key regulatory factors and metabolic pathways associated with curd formation and development in broccoli.Frontiers in plant science · 2024Article
- Genetic dissection of morphological variation between cauliflower and a rapid cycling Brassica oleracea line.G3 (Bethesda, Md.) · 2023Article
- Upregulation of tandem duplicated BoFLC1 genes is associated with the non-flowering trait in Brassica oleracea var. capitata.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Epistatic interactions among multiple copies ofAoB PLANTS · 2023Article
- A 215-bp indel at intron I of BoFLC2 affects flowering time in Brassica oleracea var. capitata during vernalization.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Non-vernalization requirement in Chinese kale caused by loss of BoFLC and low expressions of its paralogs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Article
- Validation of a novel associative transcriptomics pipeline in Brassica oleracea: identifying candidates for vernalisation response.BMC genomics · 2021Article
- Genome sequencing sheds light on the contribution of structural variants to Brassica oleracea diversification.BMC biology · 2021Article
- Total FLC transcript dynamics from divergent paralogue expression explains flowering diversity in Brassica napus.The New phytologist · 2021Article
- A Vernalization Response in a Winter Safflower (Frontiers in plant science · 2021Article
- QTL-seq identifies BnaFT.A02 and BnaFLC.A02 as candidates for variation in vernalization requirement and response in winter oilseed rape (Brassica napus).Plant biotechnology journal · 2020Article
- Noncoding SNPs influence a distinct phase of Polycomb silencing to destabilize long-term epigenetic memory atGenes & development · 2020Article
- From landrace to modern hybrid broccoli: the genomic and morphological domestication syndrome within a diverseHorticulture research · 2020Article
- Genome Triplication Leads to Transcriptional Divergence ofFrontiers in plant science · 2020Review
- The vernalisation regulator FLOWERING LOCUS C is differentially expressed in biennial and annual Brassica napus.Scientific reports · 2019Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Variation in flowering time and response to overwintering has been exploited to breed brassica vegetables that can be harvested year-round. Our knowledge of flowering time control now enables the investigation of the molecular basis of this important variation. Here, we show that a major determinant of heading date variation in Brassica oleracea is from variation in vernalization response through allelic variation at FLOWERING LOCUS C.C2 (BoFLC4). We characterize two alleles of BoFLC.C2 that are both functional and confer a requirement for vernalization, but they show distinct expression dynamics in response to cold. Complementation experiments in Arabidopsis thaliana revealed that the allelic variation results from cis polymorphism at BoFLC.C2, which quantitatively influences the degree of cold-induced epigenetic silencing. This results in one allelic variant conferring consistently later heading under both glasshouse and field conditions through reduced environmental sensitivity. Our results suggest that breeding of brassica varieties for commercially valuable variation in heading date has been achieved through the selection of cis polymorphism at FLC, similar to that underpinning natural variation in A. thaliana. This understanding will allow for the selection of alleles with distinct sensitivities to cold and robust heading dates under variable climatic conditions, and will facilitate the breeding of varieties more resistant to climate change.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.