ArticleOncotarget2016
The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- Review
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- Aflatoxin B1: Challenges and Strategies for the Intestinal Microbiota and Intestinal Health of Monogastric Animals.Toxins · 2025Review
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- Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation.Chemical research in toxicology · 2024Article
- AFB1 and OTA Promote Immune Toxicity in Human LymphoBlastic T Cells at Transcriptomic Level.Foods (Basel, Switzerland) · 2023Article
- Mycotoxin source and its exposure causing mycotoxicoses.Bioinformation · 2023Review
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- Modulatory Effects ofAnimals : an open access journal from MDPI · 2022Article
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- Aflatoxin B1 targeted gene expression profiles in human placental primary trophoblast cells.Current research in toxicology · 2022Article
- Review
- Factors Affecting the Readmission of Patients with Pancreatic Cancer after Surgery.Applied bionics and biomechanics · 2022Article
- Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review.Journal of fungi (Basel, Switzerland) · 2021Review
- Article
- Aflatoxin B1 Induces Neurotoxicity through Reactive Oxygen Species Generation, DNA Damage, Apoptosis, and S-Phase Cell Cycle Arrest.International journal of molecular sciences · 2020Article
- Article
- Sterigmatocystin moderately induces oxidative stress in male Wistar rats after short-term oral treatment.Mycotoxin research · 2020Article
- Chronic and Acute Toxicities of Aflatoxins: Mechanisms of Action.International journal of environmental research and public health · 2020Review
- Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aflatoxin B1 (AFB1) has potent hepatotoxic, carcinogenic, genotoxic, immunotoxic and other adverse effects in human and animals. The aim of this study was to investigate the molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum of broilers. Broilers, as experimental animals, were fed 0.6 mg/kg AFB1 diet for 3 weeks. Our results showed that AFB1 reduced the jejunal villus height, villus height/crypt ratio and caused G2/M cell cycle arrest. The G2/M cell cycle was accompanied by the increase of ataxia telangiectasia mutated (ATM), p53, Chk2, p21 protein and mRNA expression, and the decrease of Mdm2, cdc25C, cdc2, cyclin B and proliferating cell nuclear antigen protein and mRNA expression. In conclusion, AFB1 blocked G2/M cell cycle by ATM pathway in the jejunum of broilers.
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Registered trials
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