ArticlePLoS neglected tropical diseases2016
Molecular Epidemiology and Antibiotic Susceptibility of Vibrio cholerae Associated with a Large Cholera Outbreak in Ghana in 2014.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Cholera burden in Ghana: a systematic review and meta-analysis of prevalence, antimicrobial resistance and risk factors.International health · 2025Pooled it
- Risk factors for cholera mortality: A scoping review.Tropical medicine & international health : TM & IH · 2025Article
- Cholera Outbreaks in Low- and Middle-Income Countries in the Last Decade: A Systematic Review and Meta-Analysis.Microorganisms · 2024Review
- Genomic insights into the 2022-2023Vibrio cholerae outbreak in Malawi.Nature communications · 2024Article
- Cholera rages in Africa and the Middle East: A narrative review on challenges and solutions.Health science reports · 2024Review
- Global Patterns of Trends in Cholera Mortality.Tropical medicine and infectious disease · 2023Article
- Attenuation of quorum sensing system and virulence inFrontiers in microbiology · 2023Article
- Resistance ofFrontiers in pharmacology · 2023Review
- Prediction of Antibiotic Susceptibility Profiles ofFrontiers in microbiology · 2022Article
- Phylogenetic and antimicrobial drug resistance analysis ofMicrobial genomics · 2021Article
- A molecular and epidemiological study of Vibrio cholerae isolates from cholera outbreaks in southern Ghana.PloS one · 2020Article
- Characterisation ofThe Pan African medical journal · 2020Article
- Bayesian Random Effect Modeling for analyzing spatial clustering of differential time trends of diarrhea incidences.Scientific reports · 2019Article
- Review
- Investigating the virulence genes and antibiotic susceptibility patterns of Vibrio cholerae O1 in environmental and clinical isolates in Accra, Ghana.BMC infectious diseases · 2019Article
- Phenotypic and Genotypic Antimicrobial Resistance Traits ofFrontiers in microbiology · 2019Article
- Review of molecular subtyping methodologies used to investigate outbreaks due to multidrug-resistant enteric bacterial pathogens in sub-Saharan Africa.African journal of laboratory medicine · 2019Review
- Environmental surveillance for Vibrio cholerae in selected households' water storage systems in Accra Metropolitan Area (AMA) prior to the 2014 cholera outbreak in Accra, Ghana.Environmental science and pollution research international · 2018Article
- Antimicrobial resistance ofAfrican journal of laboratory medicine · 2018Review
- Vibrio Pathogens: A Public Health Concern in Rural Water Resources in Sub-Saharan Africa.International journal of environmental research and public health · 2017Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundGhana is affected by regular cholera epidemics and an annual average of 3,066 cases since 2000. In 2014, Ghana experienced one of its largest cholera outbreaks within a decade with more than 20,000 notified infections. In order to attribute this rise in cases to a newly emerging strain or to multiple simultaneous outbreaks involving multi-clonal strains, outbreak isolates were characterized, subtyped and compared to previous epidemics in 2011 and 2012. METHODOLOGY/PRINCIPAL
findingsSerotypes, biotypes, antibiotic susceptibilities were determined for 92 Vibrio cholerae isolates collected in 2011, 2012 and 2014 from Southern Ghana. For a subgroup of 45 isolates pulsed-field gel electrophoresis, multilocus sequence typing and multilocus-variable tandem repeat analysis (MLVA) were performed. Eighty-nine isolates (97%) were identified as ctxB (classical type) positive V. cholerae O1 biotype El Tor and three (3%) isolates were cholera toxin negative non-O1/non-O139 V. cholerae. Among the selected isolates only sulfamethoxazole/trimethoprim resistance was detectable in 2011, while 95% of all 2014 isolates showed resistance towards sulfamethoxazole/trimethoprim, ampicillin and reduced susceptibility to ciprofloxacin. MLVA achieved the highest subtype discrimination, revealing 22 genotypes with one major outbreak cluster in each of the three outbreak years. Apart from those clusters genetically distant genotypes circulate during each annual epidemic. CONCLUSIONS/SIGNIFICANCE: This analysis suggests different endemic reservoirs of V. cholerae in Ghana with distinct annual outbreak clusters accompanied by the occurrence of genetically distant genotypes. Preventive measures for cholera transmission should focus on aquatic reservoirs. Rapidly emerging multidrug resistance must be monitored closely.
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Registered trials
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