ArticleAnnals of surgery2017
Computed Tomography Screening for Lung Cancer: Mediastinal Lymph Node Resection in Stage IA Nonsmall Cell Lung Cancer Manifesting as Subsolid and Solid Nodules.
Article in Annals of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Comparison of lobectomy and sublobar resection for stage I non-small cell lung cancer: a meta-analysis based on randomized controlled trials.Frontiers in oncology · 2023Pooled it
- Mediastinal lymph node metastasis pattern of subsolid non-small cell lung cancer.Journal of thoracic disease · 2026Article
- Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules.Nature communications · 2025Article
- A new selective mediastinal lymph node dissection for clinical peripheral stage IA invasive non-small-cell lung cancer: a propensity-score matching study.Journal of thoracic disease · 2024Article
- Article
- Examining the role of healthcare access in racial/ethnic disparities in receipt of provider-patient discussions about smoking: A latent class analysis.Preventive medicine · 2021Article
- Preoperative consolidation-to-tumor ratio is effective in the prediction of lymph node metastasis in patients with pulmonary ground-glass component nodules.Thoracic cancer · 2021Article
- Predictors of upstage and treatment strategies for stage IA lung cancers after sublobar resection for adenocarcinoma in situ and minimally invasive adenocarcinoma.Translational lung cancer research · 2021Article
- Lymphadenectomy is Unnecessary for Pure Ground-Glass Opacity Pulmonary Nodules.Journal of clinical medicine · 2020Article
- Comprehensive Study of Surgical Treated Lung Adenocarcinoma with Ground Glass Nodule Component.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Solid part size is an important predictor of nodal metastasis in lung cancer with a subsolid tumor.BMC pulmonary medicine · 2018Article
- Minimally invasive thoracic surgery: beyond surgical access.Journal of thoracic disease · 2018Review
- Should a therapeutic strategy be based on how the disease was diagnosed?Journal of thoracic disease · 2018Article
- Surgery for mediastinal lymph node and early stage lung cancer: individualized practice based on clinical database.Journal of thoracic disease · 2018Article
- Mediastinal lymph node resection in stage IA non-small cell lung cancer with small nodule: is it mandatory?Journal of thoracic disease · 2017Article
- Four percent matters.Journal of thoracic disease · 2017Article
- Risk factors of lymph node metastasis in lung squamous cell carcinoma of 3 cm or less in diameter.Medicine · 2017Article
- Management of screening-detected stage I lung cancer.Journal of thoracic disease · 2016Article
- The importance of the regimen of screening in maximizing the benefit and minimizing the harms.Annals of translational medicine · 2016Review
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
20 authors at 11 institutions in 1 country.
Funding
Abstract
objectiveTo compare long-term survival rates of patients with first, primary, clinical stage IA nonsmall cell lung cancer from a large cohort undergoing computed tomography screening with and without mediastinal lymph node resection (MLNR) under an Institutional Review Board-approved common protocol from 1992 to 2014.
backgroundAssessing survival differences of patients with and without MLNR manifesting as solid and subsolid nodules.
methodsLong-term Kaplan-Meier (K-M) survival rates for those with and without MLNR were compared and Cox regression analyses were used to adjust for demographic, computed tomography, and surgical covariates.
resultsThe long-term K-M rates for 462 with and 145 without MLNR was 92% versus 96% (P = 0.19), respectively. For 203 patients with a subsolid nodule, 151 with and 52 without MLNR, the rate was 100%. For the 404 patients with a solid nodule, 311 with and 93 without MLNR, the rate was 87% versus 94% (P = 0.24) and Cox regression showed no statistically significant difference (P = 0.28) when adjusted for all covariates. Risk of dying increased significantly with increasing decades of age (hazard ratio [HR] 2.3, 95% confidence interval [CI] 1.4-3.8), centrally located tumor (HR 2.5, 95% CI 1.2-5.2), tumor size 21 to 30 mm (HR 2.7, 95% CI 1.2-6.0), and invasion beyond the lung stroma (HR 3.0, 95% CI 1.4-6.1). For the 346 patients with MLNR, tumor size was 20 mm or less; K-M rates for the 269 patients with and 169 patients without MLNR were also not significantly different (HR 2.1, P = 0.24).
conclusionsIt is not mandatory to perform MLNR when screen-diagnosed nonsmall cell lung cancer manifests as a subsolid nodule.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.