Evidence map›Paper›PMID 27232252›Full record

ArticleAnnals of surgery2017

Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma: Stage Adjusted Analysis From a Single High-volume Center in Asia.

Hong Jae Chon, Woo Jin Hyung, Chan Kim, Sohee Park, Jie-Hyun Kim, Chan Hyuk Park, Joong Bae Ahn, Hyunki Kim, Hyun Cheol Chung, Sun Young Rha and 2 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 2 syntheses or guidelines pooled it, 158 citations in OpenAlex.

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  6. The Prognostic Significance of Preoperative StagingMolecular imaging and radionuclide therapy · 2026
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Hong Jae Chon*Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA Univerisity, Seongnam, Korea †Yonsei Graduate School, Yonsei University College of Medicine, Seoul, Korea ‡Department of Surgery, Yonsei University College of Medicine, Seoul, Korea §Department of Biostatistics, Graduate School of Public Health, Yonsei University, Seoul, Korea ||Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea ¶Department of internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicinem Guri, Korea **Department of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea ††Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Woo Jin Hyung
Chan Kim
Sohee Park
Jie-Hyun Kim
Chan Hyuk Park
Joong Bae Ahn
Hyunki Kim
Hyun Cheol Chung
Sun Young Rha
Sung Hoon Noh
Hei-Cheul Jeung
Yonsei University · KRCHA University Bundang Medical Center · KRGangnam Severance Hospital · KRHanyang University Guri Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to analyze the clinicopathologic characteristics and prognosis of signet ring cell carcinoma (SRC) according to disease status (early vs advanced gastric cancer) in gastric cancer patients.

backgroundThe prognostic implication of gastric SRC remains a subject of debate.

methodsA retrospective analysis was performed using the clinical records of 7667 patients including 1646 SRC patients who underwent radical gastrectomy between 2001 and 2010. A further analysis was also performed after dividing patients into three groups according to histologic subtype: SRC, well-to-moderately differentiated (WMD), and poorly differentiated adenocarcinoma.

resultsSRC patients have younger age distribution and female predominance compared with other histologic subtypes. Notably, the distribution of T stage of SRC patients was distinct, located in extremes (T1: 66.2% and T4: 20%). Moreover, the prognosis of SRC in early gastric cancer and advanced gastric cancer was contrasting. In early gastric cancer, SRC demonstrated more favorable prognosis than WMD after adjusting for age, sex, and stage. In contrast, SRC in advanced gastric cancer displayed worse prognosis than WMD. As stage increased, survival outcomes of SRC continued to worsen compared with WMD.

conclusionsAlthough conferring favorable prognosis in early stage, SRC has worse prognostic impact as disease progresses. The longstanding controversy of SRC on prognosis may result from disease status at presentation, which leads to differing prognosis compared with tubular adenocarinoma.

Indexed as

Cause of DeathAdenocarcinomaAdultAgedAsiaBiopsy, NeedleCarcinoma, Signet Ring CellCohort StudiesDisease-Free SurvivalDisease ProgressionFemaleGastrectomyHospitals, High-VolumeHumansImmunohistochemistryKaplan-Meier Estimate

Identifiers

PMID27232252
PMCPMC5389602
OpenAlexW2404754214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.