Evidence map›Paper›PMID 27232157›Full record

ArticleCell cycle (Georgetown, Tex.)2016

Prognostic significance of monocarboxylate transporter expression in oral cavity tumors.

Susana Simões-Sousa, Sara Granja, Céline Pinheiro, Daniela Fernandes, Adhemar Longatto-Filho, Ana Carolina Laus, Cira Danielle Casado Alves, J M Suárez-Peñaranda, Mario Pérez-Sayáns, Andre Lopes Carvalho and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  9. Transcriptional expression of SLC16A7 as a biomarker of occult lymph node metastases in patients with head and neck squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Susana Simões-Sousaa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
Sara Granjaa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
Céline Pinheiroa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
Daniela Fernandesa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
Adhemar Longatto-Filhoa Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
Ana Carolina Lausd Molecular Oncology Research Center, Barretos Cancer Hospital , Barretos , Sao Paulo , Brazil.
Cira Danielle Casado Alvesf Head and Neck Surgery Department , Barretos Cancer Hospital , Barretos , Sao Paulo , Brazil.
J M Suárez-Peñarandag Department of Pathology and Forensic Sciences , University Hospital and School of Medicine of Santiago de Compostela, Santiago de Compostela , A Coruña , Spain.
Mario Pérez-Sayánsh Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Health Research Institute of Santiago (IDIS), Santiago de Compostela , A Coruña , Spain.
Andre Lopes Carvalhod Molecular Oncology Research Center, Barretos Cancer Hospital , Barretos , Sao Paulo , Brazil.
Fernando C Schmitti IPATIMUP - Institute of Molecular Pathology and Immunology of University of Porto , Porto , Portugal.
Abel García-Garcíah Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Health Research Institute of Santiago (IDIS), Santiago de Compostela , A Coruña , Spain.
Fatima Baltazara Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho , Braga , Portugal.
University of Minho · PTHospital de Câncer de Barretos · BRInstituto de Investigación Sanitaria de Santiago · ESUniversidade de Santiago de Compostela · ESUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHead and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer. The majority of patients present advanced stage disease and has poor survival. Therefore, it is imperative to search for new biomarkers and new alternative and effective treatment options. Most cancer cells rely on aerobic glycolysis to generate energy and metabolic intermediates. This phenotype is a hallmark of cancer, characterized by an increase in glucose consumption and production of high amounts of lactate. Consequently, cancer cells need to up-regulate many proteins and enzymes related with the glycolytic metabolism. Thus, the aim of this study was to characterize metabolic phenotype of oral cavity cancers (OCC) by assessing the expression pattern of monocarboxylate transporters (MCTs) 1, 2 and 4 and other proteins related with the glycolytic phenotype. MATERIAL AND

methodsWe evaluated the immunohistochemical expression of MCT1, MCT4, CD147, GLUT1 and CAIX in 135 human samples of OCC and investigated the correlation with clinicopathological parameters and the possible association with prognosis.

resultsWe observed that all proteins analyzed presented significantly higher plasma membrane expression in neoplastic compared to non-neoplastic samples. MCT4 was significantly associated with T-stage and advanced tumoral stage, while CD147 was significantly correlated with histologic differentiation. Interestingly, tumors expressing both MCT1 and MCT4 but negative for MCT2 were associated with shorter overall survival.

conclusionOverexpression of MCT1/4, CD147, GLUT1 and CAIX, supports previous findings of metabolic reprograming in OCC, warranting future studies to explore the hyper-glycolytic phenotype of these tumors. Importantly, MCT expression revealed to have a prognostic value in OCC survival.

Indexed as

FemaleHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedMonocarboxylic Acid TransportersMouthMouth NeoplasmsPrognosisMonocarboxylic Acid Transportersaerobic glycolysishead and neck cancerlactate transportmonocarboxylate transporters

Identifiers

PMID27232157
PMCPMC4968907
OpenAlexW2403467521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.