ReviewCA: a cancer journal for clinicians2016
State of the science on prevention and screening to reduce melanoma incidence and mortality: The time is now.
Review in CA: a cancer journal for clinicians, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03817125 (A Multicenter Phase 1b Randomized, Placebo-controlled, Blinded Study to Evaluate the Safety, Tolerability and Efficacy of Microbiome Study Intervention Administration in Combination With Anti-PD-1 Therapy in Adult Patients With Unresectable or Metastatic Melanoma), which is not on this map. Cited by 97 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Phase 1b Randomized, Placebo-controlled, Blinded Study to Evaluate the Safety, Tolerability and Efficacy of Microbiome Study Intervention Administration in Combination With Anti-PD-1 Therapy in Adult Patients With Unresectable or Metastatic Melanoma
Who cites it
97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018Pooled it
- Guideline
- Solar UV Measured under Built-Shade in Public Parks: Findings from a Randomized Trial in Denver and Melbourne.International journal of environmental research and public health · 2022Trial
- Article
- Assessment of behaviors, attitudes, and awareness regarding skin cancer among polish medical and non-medical students: comparative analysis.Frontiers in oncology · 2026Article
- Trends and disparities in skin malignant neoplasm mortality in the United States: a 22-year trend analysis based on CDC WONDER Data (1999-2020).Frontiers in oncology · 2026Article
- Temporal trends in long-term relative survival of cutaneous verrucous carcinoma: a period analysis from a large-scale SEER-based cohort.Frontiers in medicine · 2026Article
- Lifestyle-Based Approaches to Cancer Prevention and Treatment: Diet, Physical Activity, and Integrative Strategies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Real-World Outcomes of Adjuvant Therapy in Stage III Melanoma and the Impact of Somatic Mutations.Cancer medicine · 2025Article
- Automatic melanoma and non-melanoma skin cancer diagnosis using advanced adaptive fine-tuned convolution neural networks.Discover oncology · 2025Article
- Integrated analysis of molecular and clinical features associated with overall survival in melanoma patients with brain metastasis.Acta neuropathologica communications · 2025Article
- Application of adoptive cell therapy in malignant melanoma.Journal of translational medicine · 2025Review
- Analysis of facilitators of and barriers to enactment of state regulation of indoor tanning by minors.Translational behavioral medicine · 2025Article
- Review
- Descriptive analysis of municipal policies addressing shade in eight southwest and northeast states in the United States.Frontiers in public health · 2025Article
- Unveiling Melanoma: A Deep Dive into Disparities at a Latin-American Cancer Institute.Annals of surgical oncology · 2024Article
- BCN20000: Dermoscopic Lesions in the Wild.Scientific data · 2024Article
- Iris Pigmented Lesions and Risk of Cutaneous Melanoma: Case-Control Study in Lithuania.Journal of personalized medicine · 2024Article
- Article
- Molecular and functional anticancer effects of GLP/G9a inhibition by UNC0646 in MeWo melanoma cells.Heliyon · 2024Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Answer questions and earn CME/CNE Although overall cancer incidence rates are decreasing, melanoma incidence rates continue to increase about 3% annually. Melanoma is a significant public health problem that exacts a substantial financial burden. Years of potential life lost from melanoma deaths contribute to the social, economic, and human toll of this disease. However, most cases are potentially preventable. Research has clearly established that exposure to ultraviolet radiation increases melanoma risk. Unprecedented antitumor activity and evolving survival benefit from novel targeted therapies and immunotherapies are now available for patients with unresectable and/or metastatic melanoma. Still, prevention (minimizing sun exposure that may result in tanned or sunburned skin and avoiding indoor tanning) and early detection (identifying lesions before they become invasive or at an earlier stage) have significant potential to reduce melanoma incidence and melanoma-associated deaths. This article reviews the state of the science on prevention and early detection of melanoma and current areas of scientific uncertainty and ongoing debate. The US Surgeon General's Call to Action to Prevent Skin Cancer and US Preventive Services Task Force reviews on skin cancer have propelled a national discussion on melanoma prevention and screening that makes this an extraordinary and exciting time for diverse disciplines in multiple sectors-health care, government, education, business, advocacy, and community-to coordinate efforts and leverage existing knowledge to make major strides in reducing the public health burden of melanoma in the United States. CA Cancer J Clin 2016;66:460-480. © 2016 American Cancer Society.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.